7rze
From Proteopedia
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| - | ==== | + | ==Insulin Degrading Enzyme pO/pC== |
| - | <StructureSection load='7rze' size='340' side='right'caption='[[7rze]]' scene=''> | + | <StructureSection load='7rze' size='340' side='right'caption='[[7rze]], [[Resolution|resolution]] 3.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7rze]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RZE FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rze OCA], [https://pdbe.org/7rze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rze RCSB], [https://www.ebi.ac.uk/pdbsum/7rze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rze ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rze OCA], [https://pdbe.org/7rze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rze RCSB], [https://www.ebi.ac.uk/pdbsum/7rze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rze ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Liang WG]] |
| + | [[Category: Mancl JM]] | ||
| + | [[Category: Tang WJ]] | ||
Revision as of 19:24, 7 September 2022
Insulin Degrading Enzyme pO/pC
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