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7y1t
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2== |
| - | <StructureSection load='7y1t' size='340' side='right'caption='[[7y1t]]' scene=''> | + | <StructureSection load='7y1t' size='340' side='right'caption='[[7y1t]], [[Resolution|resolution]] 3.24Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7y1t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y1T FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y1t OCA], [https://pdbe.org/7y1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y1t RCSB], [https://www.ebi.ac.uk/pdbsum/7y1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y1t ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y1t OCA], [https://pdbe.org/7y1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y1t RCSB], [https://www.ebi.ac.uk/pdbsum/7y1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y1t ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ITAV_HUMAN ITAV_HUMAN]] The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Z | + | [[Category: Duan Z]] |
| + | [[Category: Zhang Z]] | ||
Revision as of 16:50, 7 September 2022
Complex of integrin alphaV/beta8 and L-TGF-beta1 at a ratio of 1:2
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