8a43
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Human RNA polymerase I== |
| - | <StructureSection load='8a43' size='340' side='right'caption='[[8a43]]' scene=''> | + | <StructureSection load='8a43' size='340' side='right'caption='[[8a43]], [[Resolution|resolution]] 4.09Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[8a43]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A43 FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a43 OCA], [https://pdbe.org/8a43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a43 RCSB], [https://www.ebi.ac.uk/pdbsum/8a43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a43 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a43 OCA], [https://pdbe.org/8a43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a43 RCSB], [https://www.ebi.ac.uk/pdbsum/8a43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a43 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/RPA2_HUMAN RPA2_HUMAN]] Treacher-Collins syndrome. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/RPA2_HUMAN RPA2_HUMAN]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.<ref>PMID:16809778</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Abascal-Palacios G]] |
| + | [[Category: Bernecky C]] | ||
| + | [[Category: Bleckmann A]] | ||
| + | [[Category: Bruckmann A]] | ||
| + | [[Category: Daiss JL]] | ||
| + | [[Category: Engel C]] | ||
| + | [[Category: Fuertges T]] | ||
| + | [[Category: Heiss FB]] | ||
| + | [[Category: Hoecherl M]] | ||
| + | [[Category: Lamour V]] | ||
| + | [[Category: Mars JC]] | ||
| + | [[Category: Moss T]] | ||
| + | [[Category: Panov K]] | ||
| + | [[Category: Pilsl M]] | ||
| + | [[Category: Ramsay E]] | ||
| + | [[Category: Rudack T]] | ||
| + | [[Category: Straub K]] | ||
| + | [[Category: Tluckova K]] | ||
| + | [[Category: Vannini A]] | ||
Revision as of 19:36, 7 September 2022
Human RNA polymerase I
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Categories: Homo sapiens | Large Structures | Abascal-Palacios G | Bernecky C | Bleckmann A | Bruckmann A | Daiss JL | Engel C | Fuertges T | Heiss FB | Hoecherl M | Lamour V | Mars JC | Moss T | Panov K | Pilsl M | Ramsay E | Rudack T | Straub K | Tluckova K | Vannini A
