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4b46

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CetZ1 from Haloferax volcanii - GDP bound monomer

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Retrieved from "http://52.214.119.220/wiki/index.php/4b46"

Categories: Haloferax volcanii | Large Structures | Aylett CHS | Duggin IG | Lowe J

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 <StructureSection load='4b46' size='340' side='right'caption='[[4b46]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4b46]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_29605 Atcc 29605]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B46 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4b46]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloferax_volcanii Haloferax volcanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B46 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4b45|4b45]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b46 OCA], [https://pdbe.org/4b46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b46 RCSB], [https://www.ebi.ac.uk/pdbsum/4b46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b46 ProSAT]</span></td></tr>
 </table>
-<div style="background-color:#fffaf0;">
+== Function ==
-== Publication Abstract from PubMed ==
+[https://www.uniprot.org/uniprot/CETZ1_HALVD CETZ1_HALVD] Involved in cell shape control. Essential for the development of a rod-shaped cell type required for efficient swimming.<ref>PMID:25533961</ref>
-Tubulin is a major component of the eukaryotic cytoskeleton, controlling cell shape, structure and dynamics, whereas its bacterial homologue FtsZ establishes the cytokinetic ring that constricts during cell division. How such different roles of tubulin and FtsZ evolved is unknown. Studying Archaea may provide clues as these organisms share characteristics with Eukarya and Bacteria. Here we report the structure and function of proteins from a distinct family related to tubulin and FtsZ, named CetZ, which co-exists with FtsZ in many archaea. CetZ X-ray crystal structures showed the FtsZ/tubulin superfamily fold, and one crystal form contained sheets of protofilaments, suggesting a structural role. However, inactivation of CetZ proteins in Haloferax volcanii did not affect cell division. Instead, CetZ1 was required for differentiation of the irregular plate-shaped cells into a rod-shaped cell type that was essential for normal swimming motility. CetZ1 formed dynamic cytoskeletal structures in vivo, relating to its capacity to remodel the cell envelope and direct rod formation. CetZ2 was also implicated in H. volcanii cell shape control. Our findings expand the known roles of the FtsZ/tubulin superfamily to include archaeal cell shape dynamics, suggesting that a cytoskeletal role might predate eukaryotic cell evolution, and they support the premise that a major function of the microbial rod shape is to facilitate swimming.
-CetZ tubulin-like proteins control archaeal cell shape.,Duggin IG, Aylett CH, Walsh JC, Michie KA, Wang Q, Turnbull L, Dawson EM, Harry EJ, Whitchurch CB, Amos LA, Lowe J Nature. 2014 Dec 22. doi: 10.1038/nature13983. PMID:25533961<ref>PMID:25533961</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 4b46" style="background-color:#fffaf0;"></div>
 ==See Also==
@@ Line 24: / Line 17: @@
 __TOC__
 </StructureSection>
-[[Category: Atcc 29605]]
+[[Category: Haloferax volcanii]]
 [[Category: Large Structures]]
-[[Category: Aylett, C H.S]]
+[[Category: Aylett CHS]]
-[[Category: Duggin, I G]]
+[[Category: Duggin IG]]
-[[Category: Lowe, J]]
+[[Category: Lowe J]]
-[[Category: Archaea]]
-[[Category: Cell shape]]
-[[Category: Cytoskeleton]]
-[[Category: Structural protein]]
-[[Category: Tubulin]]

4b46

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CetZ1 from Haloferax volcanii - GDP bound monomer

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