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4b4s

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Current revision (10:56, 9 May 2024) (edit) (undo)
 
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<StructureSection load='4b4s' size='340' side='right'caption='[[4b4s]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4b4s' size='340' side='right'caption='[[4b4s]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4b4s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B4S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B4S FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4b4s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B4S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B4S FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v6q|2v6q]], [[2vm6|2vm6]], [[2wh6|2wh6]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b4s OCA], [https://pdbe.org/4b4s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b4s RCSB], [https://www.ebi.ac.uk/pdbsum/4b4s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b4s ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b4s OCA], [https://pdbe.org/4b4s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b4s RCSB], [https://www.ebi.ac.uk/pdbsum/4b4s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b4s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/B2L10_HUMAN B2L10_HUMAN]] Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.<ref>PMID:11278245</ref> [[https://www.uniprot.org/uniprot/B2L11_HUMAN B2L11_HUMAN]] Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.<ref>PMID:9430630</ref> <ref>PMID:11734221</ref> <ref>PMID:12019181</ref> <ref>PMID:11997495</ref> <ref>PMID:15147734</ref> <ref>PMID:15486195</ref>
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[https://www.uniprot.org/uniprot/B2L10_HUMAN B2L10_HUMAN] Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK.<ref>PMID:11278245</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hinds, M G]]
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[[Category: Hinds MG]]
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[[Category: Kvansakul, M]]
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[[Category: Kvansakul M]]
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[[Category: Rautureau, G J.P]]
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[[Category: Rautureau GJP]]
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[[Category: Apoptosis]]
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Current revision

Crystal Structure of a pro-survival Bcl-2:Bim BH3 complex

PDB ID 4b4s

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