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4b7d

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Current revision (11:44, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4b7d' size='340' side='right'caption='[[4b7d]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
<StructureSection load='4b7d' size='340' side='right'caption='[[4b7d]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4b7d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/As_4.1526 As 4.1526]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7D FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4b7d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_venezuelae Streptomyces venezuelae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7D FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=QLE:[(3R,4S,5S,7R,9E,11R,12R)-12-ETHYL-3,5,7,11-TETRAMETHYL-2,8-BIS(OXIDANYLIDENE)-1-OXACYCLODODEC-9-EN-4-YL]+3-(DIMETHYLAMINO)PROPANOATE'>QLE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bvj|2bvj]], [[2c6h|2c6h]], [[2c7x|2c7x]], [[2ca0|2ca0]], [[2cd8|2cd8]], [[2vz7|2vz7]], [[2vzm|2vzm]], [[2whw|2whw]], [[2wi9|2wi9]], [[4b7s|4b7s]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=QLE:[(3R,4S,5S,7R,9E,11R,12R)-12-ETHYL-3,5,7,11-TETRAMETHYL-2,8-BIS(OXIDANYLIDENE)-1-OXACYCLODODEC-9-EN-4-YL]+3-(DIMETHYLAMINO)PROPANOATE'>QLE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7d OCA], [https://pdbe.org/4b7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7d RCSB], [https://www.ebi.ac.uk/pdbsum/4b7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7d ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7d OCA], [https://pdbe.org/4b7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7d RCSB], [https://www.ebi.ac.uk/pdbsum/4b7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7d ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PIKC_STRVZ PIKC_STRVZ] Catalyzes the hydroxylation of narbomycin to give rise to pikromycin, and of 10-deoxymethymycin (YC-17) to give rise to methymycin and neomethymycin during macrolide antibiotic biosynthesis. In addition, produces low amounts of neopicromycin, novapikromycin and novamethymycin. Requires the participation of a ferredoxin and a ferredoxin reductase for the transfer of electrons from NADPH to the monooxygenase.<ref>PMID:16825192</ref> <ref>PMID:19124459</ref> <ref>PMID:19833867</ref> <ref>PMID:24627965</ref> <ref>PMID:9778370</ref> <ref>PMID:9831532</ref>
==See Also==
==See Also==
*[[Cytochrome P450 hydroxylase 3D structures|Cytochrome P450 hydroxylase 3D structures]]
*[[Cytochrome P450 hydroxylase 3D structures|Cytochrome P450 hydroxylase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: As 4 1526]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Podust, L M]]
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[[Category: Streptomyces venezuelae]]
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[[Category: Monooxygenase]]
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[[Category: Podust LM]]
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[[Category: Oxidoreductase]]
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[[Category: Pikromycin biosynthesis]]
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Current revision

PikC bound to the 10-DML analog with the 3-(N,N-dimethylamino) propanoate anchoring group

PDB ID 4b7d

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