4bff

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Current revision (11:50, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4bff' size='340' side='right'caption='[[4bff]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4bff' size='340' side='right'caption='[[4bff]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bff]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Arcfl Arcfl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bff]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bfj|4bfj]], [[4bfk|4bfk]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Superoxide_reductase Superoxide reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.2 1.15.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bff OCA], [https://pdbe.org/4bff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bff RCSB], [https://www.ebi.ac.uk/pdbsum/4bff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bff ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bff OCA], [https://pdbe.org/4bff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bff RCSB], [https://www.ebi.ac.uk/pdbsum/4bff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bff ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SOR_ARCFU SOR_ARCFU]] Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide (By similarity).
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[https://www.uniprot.org/uniprot/SOR_ARCFU SOR_ARCFU] Uses electrons from reduced NADP, by way of rubredoxin and an oxidoreductase, to catalyze the reduction of superoxide to hydrogen peroxide (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Neelaredoxins are a type of superoxide reductase (SOR), which are blue 14 kDa metalloproteins with a catalytic nonhaem iron centre coordinated by four histidines and one cysteine in the ferrous form. Anaerobic organisms such as Archaeoglobus fulgidus, a hyperthermophilic sulfate-reducing archaeon, have developed defence mechanisms against toxic oxygen species in which superoxide reductases play a key role. SOR is responsible for scavenging toxic superoxide anion radicals (O(2)(*-)), catalysing the one-electron reduction of superoxide to hydrogen peroxide. Crystals of recombinant A. fulgidus neelaredoxin in the oxidized form (13.7 kDa, 125 residues) were obtained using polyethylene glycol and ammonium sulfate. These crystals diffracted to 1.9 A resolution and belonged to the tetragonal space group P4(1)2(1)2, with unit-cell parameters a = b = 75.72, c = 185.44 A. Cell-content analysis indicated the presence of a tetramer in the asymmetric unit, with a Matthews coefficient (V(M)) of 2.36 A(3) Da(-1) and an estimated solvent content of 48%. The three-dimensional structure was determined by the MAD method and is currently under refinement.
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Purification, crystallization and X-ray crystallographic analysis of Archaeoglobus fulgidus neelaredoxin.,Bandeiras TM, Romao CV, Rodrigues JV, Teixeira M, Matias PM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1;66(Pt 3):316-9. doi:, 10.1107/S1744309110000916. Epub 2010 Feb 24. PMID:20208170<ref>PMID:20208170</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4bff" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Superoxide Reductase|Superoxide Reductase]]
*[[Superoxide Reductase|Superoxide Reductase]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arcfl]]
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[[Category: Archaeoglobus fulgidus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Superoxide reductase]]
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[[Category: Bandeiras TM]]
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[[Category: Bandeiras, T M]]
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[[Category: Barradas AR]]
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[[Category: Barradas, A R]]
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[[Category: Matias PM]]
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[[Category: Matias, P M]]
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[[Category: Pinho FG]]
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[[Category: Pinho, F G]]
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[[Category: Pinto AF]]
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[[Category: Pinto, A F]]
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[[Category: Rodrigues JV]]
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[[Category: Rodrigues, J V]]
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[[Category: Romao CV]]
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[[Category: Romao, C V]]
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[[Category: Sousa CM]]
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[[Category: Sousa, C M]]
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[[Category: Teixeira M]]
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[[Category: Teixeira, M]]
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[[Category: Oxidoreductase]]
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[[Category: Oxygen detoxification]]
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Current revision

Superoxide reductase (Neelaredoxin) from Archaeoglobus fulgidus in the reduced form

PDB ID 4bff

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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