4bfi

From Proteopedia

(Difference between revisions)

Current revision

Structure of the complex of the extracellular portions of mouse CD200R and mouse CD200

Structural highlights

4bfi is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.22Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MO2R1_MOUSE

Publication Abstract from PubMed

CD200 is a widely distributed membrane glycoprotein that regulates myeloid cell activity through its interaction with an inhibitory receptor (CD200R). The interaction is of interest as a target for treating excessive inflammation and for treating leukemia. There are closely related proteins to CD200R that give activating signals making this a "paired receptor." We report X-ray crystallography structures for the inhibitory CD200R, the activating receptor CD200RLa, and a complex between CD200R and CD200. Both CD200 and CD200R contain two Ig-like domains and interact through their NH2 terminal domains compatible with immunological synapse-like interactions occurring between myeloid cells and other CD200-expressing cells. The failure of the activating receptor to bind CD200 resides in subtle changes around the interface. CD200 has been acquired by herpes viruses to mimic the host interaction. CD200R has evolved rapidly presumably driven by pathogen pressure but it may also be important in homeostasis through interactions with commensal bacteria.

Structures of CD200/CD200 Receptor Family and Implications for Topology, Regulation, and Evolution.,Hatherley D, Lea SM, Johnson S, Barclay AN Structure. 2013 Apr 17. pii: S0969-2126(13)00090-7. doi:, 10.1016/j.str.2013.03.008. PMID:23602662^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hatherley D, Lea SM, Johnson S, Barclay AN. Structures of CD200/CD200 Receptor Family and Implications for Topology, Regulation, and Evolution. Structure. 2013 Apr 17. pii: S0969-2126(13)00090-7. doi:, 10.1016/j.str.2013.03.008. PMID:23602662 doi:10.1016/j.str.2013.03.008

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4bfi"

@@ Line 3: / Line 3: @@
 <StructureSection load='4bfi' size='340' side='right'caption='[[4bfi]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4bfi]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFI FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4bfi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BFI FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.22&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bfe|4bfe]], [[4bfg|4bfg]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bfi OCA], [https://pdbe.org/4bfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bfi RCSB], [https://www.ebi.ac.uk/pdbsum/4bfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bfi ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/OX2G_MOUSE OX2G_MOUSE]] Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity).
+[https://www.uniprot.org/uniprot/MO2R1_MOUSE MO2R1_MOUSE]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 24: / Line 24: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Barclay, A N]]
+[[Category: Mus musculus]]
-[[Category: Hatherley, D]]
+[[Category: Barclay AN]]
-[[Category: Johnson, S]]
+[[Category: Hatherley D]]
-[[Category: Lea, S M]]
+[[Category: Johnson S]]
-[[Category: Ig domain]]
+[[Category: Lea SM]]
-[[Category: Immune system]]
-[[Category: Leukaemia]]
-[[Category: Leukaemia mimicry]]
-[[Category: Paired receptor]]
-[[Category: Viral mimicry]]

4bfi

From Proteopedia

Current revision

Structure of the complex of the extracellular portions of mouse CD200R and mouse CD200

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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