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4bpm

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Current revision (11:03, 9 May 2024) (edit) (undo)
 
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<StructureSection load='4bpm' size='340' side='right'caption='[[4bpm]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
<StructureSection load='4bpm' size='340' side='right'caption='[[4bpm]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bpm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BPM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bpm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BPM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LVJ:2-[[2,6-BIS(CHLORANYL)-3-[(2,2-DIMETHYLPROPANOYLAMINO)METHYL]PHENYL]AMINO]-1-METHYL-6-(2-METHYL-2-OXIDANYL-PROPOXY)-N-[2,2,2-TRIS(FLUORANYL)ETHYL]BENZIMIDAZOLE-5-CARBOXAMIDE'>LVJ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bpd|4bpd]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=LVJ:2-[[2,6-BIS(CHLORANYL)-3-[(2,2-DIMETHYLPROPANOYLAMINO)METHYL]PHENYL]AMINO]-1-METHYL-6-(2-METHYL-2-OXIDANYL-PROPOXY)-N-[2,2,2-TRIS(FLUORANYL)ETHYL]BENZIMIDAZOLE-5-CARBOXAMIDE'>LVJ</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Prostaglandin-E_synthase Prostaglandin-E synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.3 5.3.99.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpm OCA], [https://pdbe.org/4bpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bpm RCSB], [https://www.ebi.ac.uk/pdbsum/4bpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bpm OCA], [https://pdbe.org/4bpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bpm RCSB], [https://www.ebi.ac.uk/pdbsum/4bpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bpm ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:[https://omim.org/entry/246530 246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN]] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
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[https://www.uniprot.org/uniprot/LTC4S_HUMAN LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.[https://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Prostaglandin-E synthase]]
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[[Category: Synthetic construct]]
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[[Category: Caffrey, M]]
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[[Category: Caffrey M]]
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[[Category: Li, D]]
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[[Category: Li D]]
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[[Category: Olieric, V]]
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[[Category: Olieric V]]
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[[Category: Wang, M]]
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[[Category: Wang M]]
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[[Category: Anomalous dispersion]]
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[[Category: Cancer]]
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[[Category: Drug target]]
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[[Category: In meso crystallization]]
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[[Category: Inflammation]]
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[[Category: Inhibitor]]
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[[Category: Isomerase]]
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[[Category: Leukotriene c4 synthase]]
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[[Category: Lipid metabolism]]
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[[Category: Mapag]]
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[[Category: Membrane protein]]
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[[Category: Membrane-associated proteins in eicosanoid and glutathione metabolism]]
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[[Category: Microcrystal]]
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[[Category: Mpges1]]
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[[Category: Pain]]
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[[Category: S-sad]]
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[[Category: Sulfur-sad]]
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Current revision

Crystal structure of a human integral membrane enzyme

PDB ID 4bpm

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