4br3

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Current revision (11:56, 20 December 2023) (edit) (undo)
 
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<StructureSection load='4br3' size='340' side='right'caption='[[4br3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4br3' size='340' side='right'caption='[[4br3]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4br3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BR3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4br3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BR3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A4V:3-BENZYLADENINE'>A4V</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=U85:1-((4-((6-AMINO-3H-PURIN-3-YL)METHYL)BIPHENYL-4-YL)METHYL)-4-(DIMETHYLAMINO)PYRIDINIUM'>U85</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A4V:3-BENZYLADENINE'>A4V</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=U85:1-((4-((6-AMINO-3H-PURIN-3-YL)METHYL)BIPHENYL-4-YL)METHYL)-4-(DIMETHYLAMINO)PYRIDINIUM'>U85</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4br3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4br3 OCA], [https://pdbe.org/4br3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4br3 RCSB], [https://www.ebi.ac.uk/pdbsum/4br3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4br3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4br3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4br3 OCA], [https://pdbe.org/4br3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4br3 RCSB], [https://www.ebi.ac.uk/pdbsum/4br3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4br3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN]] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
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[https://www.uniprot.org/uniprot/CHKA_HUMAN CHKA_HUMAN] Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.<ref>PMID:19915674</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Conejo-Garcia, A]]
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[[Category: Conejo-Garcia A]]
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[[Category: Entrena, A]]
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[[Category: Entrena A]]
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[[Category: Hurtado-Guerrero, R]]
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[[Category: Hurtado-Guerrero R]]
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[[Category: Rubio-Ruiz, B]]
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[[Category: Rubio-Ruiz B]]
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[[Category: Sahun-Roncero, M]]
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[[Category: Sahun-Roncero M]]
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[[Category: Velazquez-Campoy, A]]
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[[Category: Velazquez-Campoy A]]
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[[Category: Transferase]]
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Current revision

Determination of potential scaffolds for human choline kinase alpha 1 by chemical deconvolution studies

PDB ID 4br3

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OCA

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