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2rv8
From Proteopedia
(Difference between revisions)
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<StructureSection load='2rv8' size='340' side='right'caption='[[2rv8]]' scene=''> | <StructureSection load='2rv8' size='340' side='right'caption='[[2rv8]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[2rv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CAS/NITR204 Mycobacterium tuberculosis CAS/NITR204]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RV8 FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv8 OCA], [https://pdbe.org/2rv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rv8 RCSB], [https://www.ebi.ac.uk/pdbsum/2rv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rv8 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv8 OCA], [https://pdbe.org/2rv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rv8 RCSB], [https://www.ebi.ac.uk/pdbsum/2rv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rv8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/R4MFJ2_MYCTX R4MFJ2_MYCTX] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Tuberculosis caused by Mycobacterium tuberculosis is a leading cause of death world-wide. The PhoP protein is required for virulence and is part of the PhoPR two-component system that regulates gene expression. The NMR-derived solution structure of the PhoP C-terminal DNA-binding domain is reported. Residues 150 to 246 form a structured domain that contains a winged helix-turn-helix motif. We provide evidence that the transactivation loop postulated to contact RNA polymerase is partially disordered in solution, and that the polypeptide that connects the DNA-binding domain to the regulatory domain is unstructured. | ||
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| + | Solution structure of the PhoP DNA-binding domain from Mycobacterium tuberculosis.,Macdonald R, Sarkar D, Amer BR, Clubb RT J Biomol NMR. 2015 Sep;63(1):111-7. doi: 10.1007/s10858-015-9965-0. Epub 2015 Jul , 25. PMID:26209027<ref>PMID:26209027</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 2rv8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis CAS/NITR204]] | ||
[[Category: Amer BR]] | [[Category: Amer BR]] | ||
[[Category: Clubb RT]] | [[Category: Clubb RT]] | ||
[[Category: Macdonald R]] | [[Category: Macdonald R]] | ||
[[Category: Sarkar D]] | [[Category: Sarkar D]] | ||
Current revision
Solution Structure of the PhoP DNA-Binding Domain from Mycobacterium tuberculosis
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