1i3q

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[[Image:1i3q.gif|left|200px]]
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[[Image:1i3q.png|left|200px]]
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==Overview==
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{{ABSTRACT_11313498}}
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Structures of a 10-subunit yeast RNA polymerase II have been derived from two crystal forms at 2.8 and 3.1 angstrom resolution. Comparison of the structures reveals a division of the polymerase into four mobile modules, including a clamp, shown previously to swing over the active center. In the 2.8 angstrom structure, the clamp is in an open state, allowing entry of straight promoter DNA for the initiation of transcription. Three loops extending from the clamp may play roles in RNA unwinding and DNA rewinding during transcription. A 2.8 angstrom difference Fourier map reveals two metal ions at the active site, one persistently bound and the other possibly exchangeable during RNA synthesis. The results also provide evidence for RNA exit in the vicinity of the carboxyl-terminal repeat domain, coupling synthesis to RNA processing by enzymes bound to this domain.
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==About this Structure==
==About this Structure==
1I3Q is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1en0 1en0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I3Q OCA].
1I3Q is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1en0 1en0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I3Q OCA].
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==Reference==
 
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Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution., Cramer P, Bushnell DA, Kornberg RD, Science. 2001 Jun 8;292(5523):1863-76. Epub 2001 Apr 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11313498 11313498]
 
[[Category: DNA-directed RNA polymerase]]
[[Category: DNA-directed RNA polymerase]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Zinc motif]]
[[Category: Zinc motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:32:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 25 19:16:54 2008''

Revision as of 16:16, 25 June 2008

Image:1i3q.png

Template:STRUCTURE 1i3q

RNA POLYMERASE II CRYSTAL FORM I AT 3.1 A RESOLUTION


Template:ABSTRACT 11313498

About this Structure

1I3Q is a Protein complex structure of sequences from Saccharomyces cerevisiae. This structure supersedes the now removed PDB entry 1en0. Full crystallographic information is available from OCA.

Page seeded by OCA on Wed Jun 25 19:16:54 2008

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