4o64
From Proteopedia
(Difference between revisions)
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==Zinc fingers of KDM2B== | ==Zinc fingers of KDM2B== | ||
| - | <StructureSection load='4o64' size='340' side='right'caption='[[4o64]]' scene=''> | + | <StructureSection load='4o64' size='340' side='right'caption='[[4o64]], [[Resolution|resolution]] 2.13Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O64 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4o64]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O64 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O64 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o64 OCA], [https://pdbe.org/4o64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o64 RCSB], [https://www.ebi.ac.uk/pdbsum/4o64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o64 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o64 OCA], [https://pdbe.org/4o64 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o64 RCSB], [https://www.ebi.ac.uk/pdbsum/4o64 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o64 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KDM2B_HUMAN KDM2B_HUMAN] Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.<ref>PMID:16362057</ref> <ref>PMID:17994099</ref> | ||
==See Also== | ==See Also== | ||
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]] | *[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith CH]] | [[Category: Arrowsmith CH]] | ||
Current revision
Zinc fingers of KDM2B
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Edwards AM | Liu K | Min J | Tempel W | Walker JR | Xu C
