7uut
From Proteopedia
(Difference between revisions)
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==Ternary complex crystal structure of secondary alcohol dehydrogenases from the Thermoanaerobacter ethanolicus mutants C295A and I86A provides better understanding of catalytic mechanism== | ==Ternary complex crystal structure of secondary alcohol dehydrogenases from the Thermoanaerobacter ethanolicus mutants C295A and I86A provides better understanding of catalytic mechanism== | ||
| - | <StructureSection load='7uut' size='340' side='right'caption='[[7uut]]' scene=''> | + | <StructureSection load='7uut' size='340' side='right'caption='[[7uut]], [[Resolution|resolution]] 1.89Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=7jnu 7jnu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UUT FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7uut]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoanaerobacter_pseudethanolicus Thermoanaerobacter pseudethanolicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=7jnu 7jnu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UUT FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uut OCA], [https://pdbe.org/7uut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uut RCSB], [https://www.ebi.ac.uk/pdbsum/7uut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uut ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2RP : (2R)-pentan-2-ol:1'>2RP : (2R)-pentan-2-ol</scene>, <scene name='pdbligand=FME : N-FORMYLMETHIONINE:1'>FME : N-FORMYLMETHIONINE</scene>, <scene name='pdbligand=K : POTASSIUM ION:1'>K : POTASSIUM ION</scene>, <scene name='pdbligand=NAP : NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE:1'>NAP : NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE</scene>, <scene name='pdbligand=ZN : ZINC ION:1'>ZN : ZINC ION</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uut OCA], [https://pdbe.org/7uut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uut RCSB], [https://www.ebi.ac.uk/pdbsum/7uut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uut ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ADH_THEBR ADH_THEBR]] Alcohol dehydrogenase with a preference for medium chain secondary alcohols, such as 2-butanol and isopropanol. Has very low activity with primary alcohols, such as ethanol. Under physiological conditions, the enzyme reduces aldehydes and 2-ketones to produce secondary alcohols. Is also active with acetaldehyde and propionaldehyde. | ||
==See Also== | ==See Also== | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Thermoanaerobacter pseudethanolicus]] | ||
[[Category: Dinh T]] | [[Category: Dinh T]] | ||
[[Category: Phillips R]] | [[Category: Phillips R]] | ||
[[Category: Rahn K]] | [[Category: Rahn K]] | ||
Revision as of 14:48, 7 September 2022
Ternary complex crystal structure of secondary alcohol dehydrogenases from the Thermoanaerobacter ethanolicus mutants C295A and I86A provides better understanding of catalytic mechanism
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