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1i4m

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[[Image:1i4m.gif|left|200px]]
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{{STRUCTURE_1i4m| PDB=1i4m | SCENE= }}
{{STRUCTURE_1i4m| PDB=1i4m | SCENE= }}
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'''Crystal structure of the human prion protein reveals a mechanism for oligomerization'''
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===Crystal structure of the human prion protein reveals a mechanism for oligomerization===
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==Overview==
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The pathogenesis of transmissible encephalopathies is associated with the conversion of the cellular prion protein, PrP(C), into a conformationally altered oligomeric form, PrP(Sc). Here we report the crystal structure of the human prion protein in dimer form at 2 A resolution. The dimer results from the three-dimensional swapping of the C-terminal helix 3 and rearrangement of the disulfide bond. An interchain two-stranded antiparallel beta-sheet is formed at the dimer interface by residues that are located in helix 2 in the monomeric NMR structures. Familial prion disease mutations map to the regions directly involved in helix swapping. This crystal structure suggests that oligomerization through 3D domain-swapping may constitute an important step on the pathway of the PrP(C) --&gt; PrP(Sc) conversion.
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(as it appears on PubMed at http://www.pubmed.gov), where 11524679 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11524679}}
==About this Structure==
==About this Structure==
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[[Category: Yee, V C.]]
[[Category: Yee, V C.]]
[[Category: Domain-swapped dimer]]
[[Category: Domain-swapped dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:34:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:24:34 2008''

Revision as of 07:24, 1 July 2008

Template:STRUCTURE 1i4m

Crystal structure of the human prion protein reveals a mechanism for oligomerization

Template:ABSTRACT PUBMED 11524679

About this Structure

1I4M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human prion protein reveals a mechanism for oligomerization., Knaus KJ, Morillas M, Swietnicki W, Malone M, Surewicz WK, Yee VC, Nat Struct Biol. 2001 Sep;8(9):770-4. PMID:11524679

Page seeded by OCA on Tue Jul 1 10:24:34 2008

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