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7t37
From Proteopedia
(Difference between revisions)
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==Activated state of 2-APB and CBD-bound wildtype rat TRPV2 in nanodiscs== | ==Activated state of 2-APB and CBD-bound wildtype rat TRPV2 in nanodiscs== | ||
| - | <StructureSection load='7t37' size='340' side='right'caption='[[7t37]]' scene=''> | + | <StructureSection load='7t37' size='340' side='right'caption='[[7t37]], [[Resolution|resolution]] 3.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T37 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7t37]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T37 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t37 OCA], [https://pdbe.org/7t37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t37 RCSB], [https://www.ebi.ac.uk/pdbsum/7t37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t37 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FZ4:2-aminoethyl+diphenylborinate'>FZ4</scene>, <scene name='pdbligand=P0T:cannabidiol'>P0T</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t37 OCA], [https://pdbe.org/7t37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t37 RCSB], [https://www.ebi.ac.uk/pdbsum/7t37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t37 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRPV2_RAT TRPV2_RAT] Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity).<ref>PMID:10201375</ref> <ref>PMID:15249591</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Ion channels 3D structures|Ion channels 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
[[Category: Gallo PN]] | [[Category: Gallo PN]] | ||
[[Category: Moiseenkova-Bell VY]] | [[Category: Moiseenkova-Bell VY]] | ||
[[Category: Protopopova AD]] | [[Category: Protopopova AD]] | ||
[[Category: Pumroy RA]] | [[Category: Pumroy RA]] | ||
Current revision
Activated state of 2-APB and CBD-bound wildtype rat TRPV2 in nanodiscs
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