Aminopeptidase 3D structures

From Proteopedia

Revision as of 09:04, 25 September 2024

3D Structures of Aminopeptidase

Updated on 25-September-2024 {{#tree:id=OrganizedByTopic|openlevels=0|

• Cysteine aminopeptidase

• • 3pw3 – PdCys-AP – Parabacteroides distasonis
    

• Glutamyl aminopeptidase or aminopeptidase A

• • 4kx7 – hGlu-AP + Zn – human
    
  • 4kx8, 4kxb – hGlu-AP + Zn + statin derivative
    
  • 4kx9, 4kxa, 4kxc, 4kxd – hGlu-AP + Zn + amino acid
    
  • 2wyr – PhGlu-AP+Co – Pyrococcus horikoshii
    
  • 3kl9 – SpGlu-AP – Streptococcus pneumonia
    

• Alanine aminopeptidase or aminopeptidase N or a-aminoacylpeptide hydrolase

• • 8jkt – APN ectodomain 1-967 – cat
    
  • 2hpo, 2dq6, 3puu, 6g8b – EcAPN - Escherichia coli
    
  • 2gtq – NmAPN – Neisseria meningitides
    
  • 5dll – FtAPN - Francisella tularensis
    
  • 3ebg – PfAla-APN - Plasmodium falciparum
    
  • 6oiu – APN – Toxoplasma gondii
    

• Alanine aminopeptidase binary complex

• • 4fyq, 5lhd - hAla-APN + Zn
    
  • 6u7e, 6u7f, 6u7g, 7vpp, 7vpq – hAPN + spike glycoprotein
    
  • 6xwd, 7aew – hAPN + 14-3-3 protein sigma
    
  • 4fke, 5lds, 5lg6, 5z65 – pAla-APN + Zn – pig
    
  • 7u0l – dAPN + spike glycoprotein - dog
    
  • 3ked – EcAPN+2,4-diaminobutyric acid
    
  • 2hpt, 2dqm – EcAPN+bestatin
    
  • 2zxg – EcAPN+transition state analog
    
  • 8t83 - PfAla-AP (mutant) + Zn
    
  • 3ebh - PfAla-APN+bestatin
    
  • 3ebi - PfAla-APN+dipeptide analog
    
  • 4r5t, 4r5v, 4r5x – PfAla-APN + inhibitor
    
  • 5dyf – NmAPN + benzyl-diaminoethylphosphonate
    
  • 4pu2, 4pvb – NmAPN + Leu analog
    
  • 4pw4 – NmAPN + Phe analog
    
  • 4qhp, 4qir, 4qme, 4qpe, 4quo – NmAPN + dipeptide analog
    
  • 4fgm – APN + Zn – Idiomarina loihiensis
    
  • 5zi5 – LpAPN + Zn – Legionella pneumophila
    
  • 5zi7 – LpAPN + Glu
    
  • 5zie – LpAPN + Asp
    
  • 7v9n, 7v9o, 7v9p, 7v9q – APN + Zn – Saccharopolyspora erythrea
    

• Alanine aminopeptidase ternary complex

• • 4fyr - hAla-APN + Zn + bestatin
    
  • 4fys - hAla-APN + Zn + angiotensin
    
  • 4fyt - hAla-APN + Zn + amastatin
    
  • 4fkh – pAla-APN + Zn + Ala
    
  • 6buy, 6bv0, 6bv1, 6bv2, 6bv3, 6bv4 – pAPN+ Zn + amino acid
    
  • 4naq, 4nz8, 4ou3 – pAla-APN + Zn + polypeptide
    
  • 4hom – pAla-APN + Zn + substance P
    
  • 4fkk – pAla-APN + Zn + bestatin
    
  • 4f5c – pAla-APN + PRCV spike protein + Zn
    
  • 3b2p, 3b2x, 3b34, 3b37, 3b3b, 3qjx, 4xo5, 4xo4, 4xo3, 4xnd, 4xnb, 4xna, 4xn9, 4xn8, 4xn7, 4xn5, 4xn4, 4xn2, 4xn1, 4xmz, 4xmx, 4xmw, 4xmv, 4xmu, 4xmt, 5yq1 – EcAPN+ Zn + amino acid
    
  • 4q4i – EcAPN+ Zn + peptide
    
  • 4q4e – EcAPN+ Zn + actinonin
    
  • 5mfr, 5mfs, 5mft – EcAPN+ Zn + aminobenzosuberone
    
  • 5yqb – EcAPN + Zn + puromycin
    
  • 5yo1 – EcAPN (mutant) + Zn + puromycin
    
  • 5yq2 – EcAPN + Zn + puromycin aminonucleoside
    
  • 8t41 – MtAla-AP + Zn + Mg - Mycobacterium tuberculosis
    
  • 8t6h – PfAPN + Zn + Mg
    
  • 8t7p – PfAPN (mutant) + Zn + Mg
    

• Aminopeptidase B

• • 6cxd – YpAPB – Yersinia pestis
    
  • 6oad, 6ov8 – EcAPB + Zn
    

• Aminopeptidase C see Dipeptidyl aminopeptidase

• Aminopeptidase M61

• • 7xyo – AP + Zn – Myxococcus fulvus
    

• Proline aminopeptidase or X-Pro aminopeptidase or aminopeptidase P or X-prolyl aminopeptidase or Xaa-Pro dipeptidase

• • 3ctz – X hPro-AP
    
  • 1wlr - Xaa EcPro-AP
    
  • 2bws, 2bwt, 2bwu, 2bwv, 2bww, 2bwx, 2bwy - Xaa EcPro-AP (mutant)
    
  • 3ovk – Xaa Pro-AP – Streptococcus pyogenes
    
  • 3il0 - Xaa Pro-AP – Streptococcus thermophilus
    
  • 2zsg – X TmPro-AP – Thermatoga maritima
    
  • 1qtr – SmPro-AP – Serratia marcescens
    
  • 1xqv – TaPro-AP (mutant) – Thermoplasma acidophilum
    
  • 3azo – SmoPro-AP – Streptomyces morookaensis
    
  • 3azp - SmoPro-AP (mutant)
    

• Proline aminopeptidase binary complex

• • 2v3x, 2v3y, 2v3z - Xaa EcPro-AP (mutant)+tripeptide
    
  • 5cnx - Xaa EcPro-AP (mutant) + Zn
    
  • 1wl6 - Xaa EcPro-AP+Mg
    
  • 1wl9, 1m35, 1jaw - Xaa EcPro-AP+Mn
    
  • 1w2m - Xaa EcPro-AP+Ca
    
  • 1n51 – Xaa EcPro-AP+apstatin
    
  • 3ig4 – Xaa Pro-AP + Mn – Bacillus anthracis
    
  • 4fkc – Xaa TsPro-AP + Cd – Thermococcus sibiricus
    
  • 4rgz – Xaa TsPro-AP + Zn
    
  • 4pv4 – YpPro-AP II + Mg
    
  • 1x2b, 1x2e, 1wm1– SmPro-AP + inhibitor
    
  • 1xqw, 1xqx, 1xqy, 1xrl, 1xrm, 1xrn, 1xro, 1xrp, 1xrq, 1xrr – TaPro-AP+polypeptide
    
  • 3azq - SmoPro-AP (mutant) + PGG
    
  • 7e5c - Pro-AP (mutant) + Mn – Pseudoalteromonas lipolytica
    

• Proline aminopeptidase higher complex

• • 1w7v, 2bh3 - Xaa EcPro-AP+Zn+Mg+polypeptide
    
  • 2bn7 - Xaa EcPro-AP+Zn+Mg+Mn+polypeptide
    
  • 2bha, 2bhd - Xaa EcPro-AP+Mg+polypeptide
    
  • 1a16 - Xaa EcPro-AP+Mn+polypeptide
    
  • 1wbq, 2bhb - Xaa EcPro-AP+Zn+Mg
    
  • 2bhc - Xaa EcPro-AP+Na+Mg
    
  • 4s2r – CePro-AP 1 + Zn - Caenorhabditis elegans
    
  • 4s2t – CePro-AP 1 + Zn + apstatin
    
  • 5wze – PaAPP + Ala + Pro – Pseudomonas aeruginosa
    

• Leucine aminopeptidase

• • 3qnf – hLeu-AP 1
    
  • 2yd0 – hLeu-AP 1 soluble domain
    
  • 3rjo - hLeu-AP 1 peptide-binding domain
    
  • 1lam, 1lap – bLue-AP – bovine
    
  • 5jm9, 4r8f – yLeu-AP 1 - yeast
    
  • 5jhc – yLeu-AP 1 (mutant)
    
  • 1gyt – EcLeu-AP
    
  • 3jru – Leu-AP – Xanthomonas oryzae
    
  • 2hc9, 2hb6– CeLeu-AP
    
  • 3h8e, 3h8f, 3h8g – Leu-AP – Pseudomonas putida
    
  • 3kqx, 3kqz, 3kr4, 3kr5 – PfLeu-AP
    
  • 3fh4, 1rtq, 2dea – VpLeu-AP – Vibrio proteolyticus
    
  • 3b35, 3b3t, 3b3v, 2anp - VpLeu-AP (mutant)
    
  • 5lhj – StrLeu-AP 2 – Streptomyces
    
  • 5ntg, 5ntf – Leu-AP – Trypanosoma cruzi
    

• Leucine aminopeptidase binary complex

• • 3mdj - hLeu-AP 1 soluble domain + inhibitor
    
  • 2ewb – bLeu-AP+zofenoprilat
    
  • 1lan, 1lcp – bLue-AP+leucine derivative
    
  • 1bll – bLue-AP+amastatin
    
  • 4ksi – toLeu-AP 1 + Mg – tomato
    
  • 5d8n – toLeu-AP 1 (mutant) + Mg
    
  • 5jgf – yLeu-AP 1 + Zn
    
  • 5jh9 – yLeu-AP 1 (mutant) + Zn
    
  • 3b3c, 3b3s, 3b3w – VpLeu-AP (mutant)+Leu derivative
    
  • 3b7i - VpLeu-AP (mutant)+Leu
    
  • 1ft7 - VpLeu-AP +Leu derivative
    
  • 3vh9 - VpLeu-AP + 8-quinolinol
    
  • 2nyq, 2iq6 – VpLeu-AP+polypeptide
    
  • 1lok – VpLeu-AP+Tris
    
  • 2prq – VpLeu-AP+Co
    
  • 1xry, 1txr – VpLeu-AP+bestatin
    
  • 3tc8 - PdLeu-AP + Zn - Parabacteroides distasonis
    
  • 4fuu - BtLeu-AP + Zn – Bacterioides thetaiotaomicron
    
  • 5lhk – StrLeu-AP 2 + Mn
    
  • 4zla, 4zi6 – Leu-AP + Zn – Helicobacter pylori
    
  • 5gne, 6esl – LpLeu-AP + Zn
    
  • 6f3k, 6r8n – PhLeu-AP + Zn
    
  • 6wvv – PvLeu-AP M17 + Zn – Plasmodium vivax
    
  • 8sw9 – PvLeu-AP M17 (mutant) + Zn
    
  • 7k5k – PvLeu-AP M17 + Mn
    
  • 7srv, 7t3v – PfLeu-AP + Zn
    

• Leucine aminopeptidase ternary complex

• • 1bpm, 1bpn – bLue-AP+Zn+Mg
    
  • 2j9a - bLue-AP+Zn + inhibitor
    
  • 3t8w, 4k3n, 4r6t, [[6eee], 7rie] – PfLeu-AP + Zn + inhibitor
    
  • 4r76, 4r7m, 4x2t – PfLeu-AP (mutant) + Zn + inhibitor
    
  • 5ntd – TbLeu-AP + Mn + bestatin – Trypanosoma brucei
    
  • 6ee2, 6eee, 8ez4 - PfLue-AP M17 +Zn + inhibitor
    
  • 7oez – AoLeu-AP + Zn + Leu – Aspergillus oryzae
    
  • 7d1e - BtLeu-AP + Zn + acetylhistamine
    
  • 7y1s - BtLeu-AP + Zn + Ni – Bacillus amyloliquefaciens
    

• Leucine-cysteine aminopeptidase or insulin-regulated aminopeptidase

• • 4p8q, 5c97, 5mj6, 8p0i – hLeu-Cys-AP + Zn
    
  • 4pj6 – hLeu-Cys-AP + Zn + lysine
    
  • 4z7i, 6ydx – hLeu-Cys-AP + Zn + peptide
    
  • 7zyf – hLeu-Cys-AP + Zn + inhibitor
    
  • 8cgp, 8cgw – hLeu-Cys-AP + Zn + malate
    

• Lysine aminopeptidase

• • 4x8i – PfLys-AP + Zn
    

• Methionine aminopeptidase

• • 2gtx, 2gu7 – EcMet-AP
    
  • 6iz7 – EcMet-AP (mutant) – Cryo EM
    
  • 3fm3 – EncMet-AP – Encephalitozoon cuniculi
    
  • 3tb5 – Met-AP – Enterococcus faecalis
    
  • 1o0x – TmMet-AP
    
  • 4km3 – SpMet-AP
    
  • 4km3, 6mrf – Met-AP – Acinetobacter baumannii
    
  • 6k26 – VcMet-AP – Vibrio cholerae
    
  • 6lvh – PyfMet-AP – Pyrococcus furiosus
    

• Methionine aminopeptidase binary complex

• • 3mr1, 3mx6 – Met-AP+Mn – Rickettsia prowazekii
    
  • 2dfi, 1xgm, 1xgn, 1xgo, 1xgs, 6m00 – PyfMet-AP+Co
    
  • 1wkm - PyfMet-AP+Mn
    
  • 4fo7, 4juq - PaMet-AP+Mn
    
  • 4fo8 - PaMet-AP+Mn + Met
    
  • 1yj3, 3ror, 4ook - MtMet-AP 2 + Co - Mycobacterium tuberculosis
    
  • 5ypj – MtMet-AP (mutant) + Co
    
  • 3pka - MtMet-AP+Mn
    
  • 3pkb, 3pkc, 3pkd, 3pke - MtMet-AP+bengamide inhibitor
    
  • 1y1n - MtMet-AP+K
    
  • 3tav – Met-AP + Mg – Mycobacterium abscessus
    
  • 3fmq, 3fmr- EncMet-AP+angiogenesis inhibitor
    
  • 1mat – EcMet-AP+Co
    
  • 2mat, 4mat, 4u76, 4u75, 4u73, 4u71, 4u70, 4u6z, 4u6w, 4u6j, 4u6e, 4u6c, 4u69, 4u1b - EcMet-AP 1 (mutant)+Co
    
  • 6izi - EcMet-AP 1 (mutant)+ peptide deformylase – Cryo EM
    
  • 6j0a - EcMet-AP 1 + trigger factor – Cryo EM
    
  • 3s6b – PfMet-AP + Fe
    
  • 4fuk – TbMet-AP + Zn
    
  • 6ksg, 6lh7 – VcMet-AP + Ni
    
  • 8onx – TtMet-AP + Mn – Thermochaetoides thermophila
    

• Methionine aminopeptidase ternary complex

• • 8bqd, 8bqx - yMet-AP 1 in ribosome – Cryo EM
    
  • 3iu7 – MtMet-AP+Mn +A02
    
  • 3iu8, 3iu9 - MtMet-AP+Ni + inhibitor
    
  • 4idy, 4iec - MtMet-AP+K + hydroxyethyl disulfide
    
  • 4if7 - MtMet-AP+K + homocysteinemethyl disulfide
    
  • 5ypd, 5yoh, 5yoi, 5yxf – MtMet-AP (mutant) + Co + Met
    
  • 1xng, 2bb7, 2bbv, 2evc, 2evm, 2evo, 2gu4, 2gu5, 2gu6, ,2p98 2p99, 2p9a, 2q92, 2q93, 2q94, 2q95, 2q96, 3d27, 4a6v, 4a6w, 8oxg – EcMet-AP+Mn+inhibitor
    
  • 2gg0, 2gg2, 2gg3, 2gg5, 2gg7, 2gg8, 2gg9, 2ggb, 2ggc, 4pnc - EcMet-AP+Co+inhibitor
    
  • 1c21, 1c22, 1c23, 1c24 - EcMet-AP +Co + methionine derivative
    
  • 1c27 - EcMet-AP +Co +norleucine
    
  • 1yvm – EcMet-AP (mutant)+Co+thiabendazole
    
  • 3mat - EcMet-AP (mutant)+Co+bestatin derivative
    
  • 8onz, 8oo0 - TtMet-AP 2 in ribosome – Cryo EM
    

• Human methionine aminopeptidase

• • 8p2k, 9f1c, 9f1d, 9fpz, 9fq0 - hMet-AP 1 in ribosome – Cryo EM
    
  • 8khm - hMet-AP 1
    
  • 2b3h, 2b3k, 8knh - hMet-AP 1 + Co
    
  • 5yr7 – hMet-AP 1 (mutant) + Co
    
  • 2gz5, 4ikr, 4iks, 4ikt, 4iku, 4hxx, 4iu6, 6lzb, 6lzc –, hMet-AP 1 + Co + inhibitor
    
  • 4fli, 4flj, 4flk, 4fll, 2nq6, 2nq7, 1yw7, 1yw8, 1yw9, 7a12, 7a13, 7a14, 7a15, 7a16 - hMet-AP 1 + Mn +inhibitor
    
  • 2g6p - hMet-AP 1 truncated+Mn+inhibitor
    
  • 5yr4, 5yr6 – hMet-AP 1 (mutant) + TNP470 + Co
    
  • 5yr5, 5ykp – hMet-AP 1 (mutant) + ovalicin + Co
    
  • 1boa - hMet-AP 2 +Co+ angiogenesis inhibitor
    
  • 1kq0, 1kq9 – hMet-AP 2 + Met
    
  • 1qzy, 1b59, 1b6a, 1bn5, 2oaz, 5d6f, 5d6e, 5cls - hMet-AP 2 +Co+inhibitor
    
  • 2adu - hMet-AP 2 (mutant) +Co+inhibitor
    
  • 6qed, 6qef, 6qeg, 6qei, 6qej, 6qeh- hMet-AP 2 + Zn + inhibitor
    
  • 5lyw, 5lyx - hMet-AP 2 (mutant) + Zn + inhibitor
    
  • 1r58, 1r5g, 1r5h, 5ji6, 5jhu, 5jfr, 5cls, 4z7m, 5jhu, 5jfr, 2ea2, 2ea4, 2ga2, 5lyw - hMet-AP 2 +Mn+inhibitor
    

• Arginine aminopeptidase

• • 5cu5 – hArg-AP 2
    
  • 4jbs – hArg-AP 2 + Zn + inhibitor
    
  • 5ab2, 5ab0 – hArg-AP 2 + Zn + peptide
    
  • 6hc6, 6hc7 – Arg-AP + Zn – Bacillus subtilis
    

• Aspartic acid aminopeptidase

• • 4dyo – hAsp-AP+aspartic hydroxamate
    
  • 3var, 3vat – bAsp-AP
    
  • 7u5h – bAsp-AP + Zn – Cryo EM
    
  • 4eme, 6pev – PfAsp-AP + Zn
    

• Asparagine aminopeptidase

• • 3c17, 2zak – EcAsn-AP (mutant)
    
  • 2zal – EcAsn-AP+Asp
    
  • 2gez – Asn-AP – Lupinus luteus
    

• Serine aminopeptidase

• • 1b65 – OaSer-AP – Ochrobactrum anthropi
    

• Cytosolic aminopeptidase

• • 3pei – FtCyt-AP
    
  • 3ij3 – Cyt-AP – Coxiella burnetii
    

• Endoplasmic reticulum aminopeptidase or ERAP1 or ERAP2

• • 3qnf – hARTS-1
    
  • 3rjo, 5j5e – hARTS-1 ERAP1 domain 530-941
    
  • 2yd0 – hARTS-1 soluble domain 46-940
    
  • 6mgq, 6q4r, 6rqx, 6ryf – hARTS-1 + phosphinic inhibitor
    
  • 7mwc – hARTS-1 + peptide
    
  • 3mdj, 6m8p, 6mgq – hARTS-1 + Zn + inhibitor
    
  • 6t6r – hARTS-1 (mutant) + Zn + inhibitor
    
  • 3se6, 5cu5 – hARTS-2
    
  • 4e36 – hARTS-2 (mutant) + Zn
    
  • 4jbs, 5k1v, 5j6s, 6ea4, 7nsk, 7nup, 7p7p, 7pfs, 7sh0, 7z28 – hARTS-2 + Zn + inhibitor
    
  • 5ab2, 5ab0 – hARTS-2 + Zn + peptide
    

• Non-specific aminopeptidase

• • 2ek8 – AnAP – Aneurinibacillus
    
  • 2ek9 – AnAP+bestatin
    
  • 1y0r, 1xfo – PhAP
    
  • 1y0y – PhAP+amastatin
    
  • 1amp - VpAP
    
  • 1cp6, 1igb – VpAP+inhibitor
    
  • 1ei5 – OaAP
    
  • 4efd – TbAP M17 + Mn
    
  • 4icq – SpAP Peps + Zn
    
  • 4icr – SpAP Peps (mutant) + Zn
    
  • 4ics – SpAP Peps (mutant) + Zn + Trp + Gly
    
  • 4wwv – AP M42 – Desulfuroccus kamchatkensis
    
  • 4p6y, 6nw5 – TmAP
    
  • 6ica – LpAP + Zn
    

• Cold-activated aminopeptidase

• • 3cia – Col-AP – Colwellia psychrerythraea
    

• Deblocking aminopeptidase

• • 2gre – DAP – Bacillus cereus
    

• Heat stable aminopeptidase

• • 2ayi – AmpT – Thermus thermophilus
    

• Aminopeptidase from Staphylococcus aureus

• • 1zjc - SaAmpS
    
  • 1qxw, 1qxy, 1qxz – SaMet-AP+Co+inhibitor
    
  • 3kzw – SaCyt-AP
    

• Stereomyces griesus aminopeptidase

• • 1xjo, 1cp7 - SGAP
    
  • 1qq9, 1f2o, 1f2p, 1tf8, 1tf9, 1tkf, 1tkh, 1tkj, 1xbu] - SGAP + amino acid
    

• Metalloaminopeptidase

• • 3q43, 3q44 – PfPFAP (mutant) + bestatin derivative
    

• β-peptidyl AP

• • 3n2w – SxBapA – Sphingosinicella xenopeptidilytica
    
  • 3n5i – SxBapA (mutant)
    
  • 3n33 – SxBapA + AEBSF
    
  • 3ndv, 3nfb – SxBapA + ampicillin
    
  • 5tzb - AP – Burkholderia
    

• M1 family AP

• • 3t8v – PfAP + Zn + Mg
    
  • 4j3b – PfAP (mutant) + Zn + Mg + Arg
    
  • 5y1w - PfLeu-AP + Zn + Mg
    
  • 5y1x - PfLeu-AP + Zn + Mg + actinonin
    
  • 4k5l, 4k5m, 4k5n, 4k5p, 4k5o, 5cbm - PfLeu-AP (mutant) + Zn + inhibitor
    
  • 5xm7, 5y19, 5y1h, 5y1k, 5y1q, 5y1r, 5y1s, 5y1t, 5y1v, 5y3i, 8ex3, 8ez2, 8svl - PfLeu-AP + Zn + Mg + inhibitor
    
  • 4zx6, 4zx5, 4zx4, 4zx5, 4zx3, 4zw8, 4zw7, 4zw6, 4zw5, 4zw3, 4zqt, 4x2u, 6ea1, 6ea2, 6eaa, 6eab, 6ee3, 6ee4, 6ee6, 6eed - PfLeu-AP (mutant) + Zn + Mg + inhibitor
    
  • 6sbq, 6sbr, 8ewz, 8eyd, 8eye, 8eyf, 8svm, 8svo - PfAla-AP + Zn + inhibitor
    
  • 3q43, 3q44 – PfAP (mutant) + bestatin derivative
    

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Tripeptidyl aminotransferase see Tripeptidyl peptidase Dipeptidyl aminotransferase see Dipeptidyl peptidase