1i51

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{{STRUCTURE_1i51| PDB=1i51 | SCENE= }}
{{STRUCTURE_1i51| PDB=1i51 | SCENE= }}
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'''CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP'''
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===CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP===
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==Overview==
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The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution. An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making extensive contacts to the residues that are essential for its catalytic activity. Strikingly, despite a reversal of relative orientation, a subset of interactions between caspase-7 and XIAP closely resemble those between caspase-7 and its tetrapeptide inhibitor DEVD-CHO. Our biochemical and structural analyses reveal that the BIR domains are dispensable for the inhibition of caspase-3 and -7. This study provides a structural basis for the design of the next-generation caspase inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 11257230 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11257230}}
==Disease==
==Disease==
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[[Category: Iap]]
[[Category: Iap]]
[[Category: Protease]]
[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:25:50 2008''

Revision as of 07:25, 1 July 2008

Image:1i51.png

Template:STRUCTURE 1i51

Contents

CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP

Template:ABSTRACT PUBMED 11257230

Disease

Known disease associated with this structure: Lymphoproliferative syndrome, X-linked, 2 OMIM:[300079]

About this Structure

1I51 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of caspase-7 inhibition by XIAP., Chai J, Shiozaki E, Srinivasula SM, Wu Q, Datta P, Alnemri ES, Shi Y, Cell. 2001 Mar 9;104(5):769-80. PMID:11257230

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