1i5c

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[[Image:1i5c.gif|left|200px]]
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{{STRUCTURE_1i5c| PDB=1i5c | SCENE= }}
{{STRUCTURE_1i5c| PDB=1i5c | SCENE= }}
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'''STRUCTURE OF CHEA DOMAIN P4 IN COMPLEX WITH ADP'''
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===STRUCTURE OF CHEA DOMAIN P4 IN COMPLEX WITH ADP===
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==Overview==
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To probe the structural basis for protein histidine kinase (PHK) catalytic activity and the prospects for PHK-specific inhibitor design, we report the crystal structures for the nucleotide binding domain of Thermotoga maritima CheA with ADP and three ATP analogs (ADPNP, ADPCP and TNP-ATP) bound with either Mg(2+) or Mn(2+). The conformation of ADPNP bound to CheA and related ATPases differs from that reported in the ADPNP complex of PHK EnvZ. Interactions of the active site with the nucleotide gamma-phosphate and its associated Mg(2+) ion are linked to conformational changes in an ATP-lid that could mediate recognition of the substrate domain. The inhibitor TNP-ATP binds CheA with its phosphates in a nonproductive conformation and its adenine and trinitrophenyl groups in two adjacent binding pockets. The trinitrophenyl interaction may be exploited for designing CheA-targeted drugs that would not interfere with host ATPases.
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The line below this paragraph, {{ABSTRACT_PUBMED_11276258}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11276258 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11276258}}
==About this Structure==
==About this Structure==
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[[Category: Simon, M I.]]
[[Category: Simon, M I.]]
[[Category: Beta-alpha sandwich]]
[[Category: Beta-alpha sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:35:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:26:39 2008''

Revision as of 07:26, 1 July 2008

Image:1i5c.png

Template:STRUCTURE 1i5c

STRUCTURE OF CHEA DOMAIN P4 IN COMPLEX WITH ADP

Template:ABSTRACT PUBMED 11276258

About this Structure

1I5C is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Nucleotide binding by the histidine kinase CheA., Bilwes AM, Quezada CM, Croal LR, Crane BR, Simon MI, Nat Struct Biol. 2001 Apr;8(4):353-60. PMID:11276258

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