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1i5j

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[[Image:1i5j.gif|left|200px]]
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{{Seed}}
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[[Image:1i5j.png|left|200px]]
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{{STRUCTURE_1i5j| PDB=1i5j | SCENE= }}
{{STRUCTURE_1i5j| PDB=1i5j | SCENE= }}
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'''NMR STRUCTURE OF HUMAN APOLIPOPROTEIN C-II IN THE PRESENCE OF SDS'''
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===NMR STRUCTURE OF HUMAN APOLIPOPROTEIN C-II IN THE PRESENCE OF SDS===
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==Overview==
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The structure and protein-detergent interactions of apolipoprotein C-II (apoC-II) in the presence of SDS micelles have been investigated using circular dichroism and heteronuclear NMR techniques applied to (15)N-labeled protein. Micellar SDS, a commonly used mimetic of the lipoprotein surface, inhibits the aggregation of apoC-II and induces a stable structure containing approximately 60% alpha-helix as determined by circular dichroism. NMR reveals the first 12 residues of apoC-II to be structurally heterogeneous and largely disordered, with the rest of the protein forming a predominantly helical structure. Three regions of helical conformation, residues 16-36, 50-56, and 63-77, are well-defined by NMR-derived constraints, with the intervening regions showing more loosely defined helical conformation. The structure of apoC-II is compared to that determined for other apolipoproteins in a similar environment. Our results shed light on the lipid interactions of apoC-II and its mechanism of lipoprotein lipase activation.
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The line below this paragraph, {{ABSTRACT_PUBMED_11331005}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11331005 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11331005}}
==About this Structure==
==About this Structure==
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1I5J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5J OCA].
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1I5J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I5J OCA].
==Reference==
==Reference==
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[[Category: Amphipathic alpha helix]]
[[Category: Amphipathic alpha helix]]
[[Category: Protein-lipid interaction]]
[[Category: Protein-lipid interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:35:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:27:09 2008''

Revision as of 07:27, 1 July 2008

Image:1i5j.png

Template:STRUCTURE 1i5j

NMR STRUCTURE OF HUMAN APOLIPOPROTEIN C-II IN THE PRESENCE OF SDS

Template:ABSTRACT PUBMED 11331005

About this Structure

1I5J is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR structure of human apolipoprotein C-II in the presence of sodium dodecyl sulfate., MacRaild CA, Hatters DM, Howlett GJ, Gooley PR, Biochemistry. 2001 May 8;40(18):5414-21. PMID:11331005

Page seeded by OCA on Tue Jul 1 10:27:09 2008

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