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1i6a

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{{STRUCTURE_1i6a| PDB=1i6a | SCENE= }}
{{STRUCTURE_1i6a| PDB=1i6a | SCENE= }}
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'''CRYSTAL STUCTURE OF THE OXIDIZED FORM OF OXYR'''
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===CRYSTAL STUCTURE OF THE OXIDIZED FORM OF OXYR===
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==Overview==
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The Escherichia coli OxyR transcription factor senses H2O2 and is activated through the formation of an intramolecular disulfide bond. Here we present the crystal structures of the regulatory domain of OxyR in its reduced and oxidized forms, determined at 2.7 A and 2.3 A resolutions, respectively. In the reduced form, the two redox-active cysteines are separated by approximately 17 A. Disulfide bond formation in the oxidized form results in a significant structural change in the regulatory domain. The structural remodeling, which leads to different oligomeric associations, accounts for the redox-dependent switch in OxyR and provides a novel example of protein regulation by "fold editing" through a reversible disulfide bond formation within a folded domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 11301006 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11301006}}
==About this Structure==
==About this Structure==
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[[Category: Oxidized form]]
[[Category: Oxidized form]]
[[Category: Oxyr regulatory domain]]
[[Category: Oxyr regulatory domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:37:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:28:41 2008''

Revision as of 07:28, 1 July 2008

Image:1i6a.png

Template:STRUCTURE 1i6a

CRYSTAL STUCTURE OF THE OXIDIZED FORM OF OXYR

Template:ABSTRACT PUBMED 11301006

About this Structure

1I6A is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis of the redox switch in the OxyR transcription factor., Choi H, Kim S, Mukhopadhyay P, Cho S, Woo J, Storz G, Ryu S, Cell. 2001 Apr 6;105(1):103-13. PMID:11301006

Page seeded by OCA on Tue Jul 1 10:28:41 2008

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