4bts
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bts]] is a 40 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila] and [https://en.wikipedia.org/wiki/Tetrahymena_thermophila_SB210 Tetrahymena thermophila SB210]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpe 4bpe], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpn 4bpn], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpo 4bpo] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpp 4bpp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BTS FirstGlance]. <br> | <table><tr><td colspan='2'>[[4bts]] is a 40 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila] and [https://en.wikipedia.org/wiki/Tetrahymena_thermophila_SB210 Tetrahymena thermophila SB210]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpe 4bpe], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpn 4bpn], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpo 4bpo] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpp 4bpp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BTS FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.703Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bts OCA], [https://pdbe.org/4bts PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bts RCSB], [https://www.ebi.ac.uk/pdbsum/4bts PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bts ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bts OCA], [https://pdbe.org/4bts PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bts RCSB], [https://www.ebi.ac.uk/pdbsum/4bts PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bts ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/I7MK25_TETTS I7MK25_TETTS] Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).[RuleBase:RU004365] | |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Eukaryotic translation initiation factors (eIFs) 1A and 1 are central players in the complex process of start-codon recognition. To improve mechanistic understanding of this process, we determined the crystal structure of the 40S ribosomal subunit in complex with eIF1A and eIF1 from Tetrahymena thermophila at a resolution of 3.7 A. It reveals the positions of the two factors on the 40S and the conformational changes that accompany their binding. | ||
| + | |||
| + | The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A.,Weisser M, Voigts-Hoffmann F, Rabl J, Leibundgut M, Ban N Nat Struct Mol Biol. 2013 Jul 14. doi: 10.1038/nsmb.2622. PMID:23851459<ref>PMID:23851459</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4bts" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Ribosome 3D structures|Ribosome 3D structures]] | *[[Ribosome 3D structures|Ribosome 3D structures]] | ||
*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]] | *[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
THE CRYSTAL STRUCTURE OF THE EUKARYOTIC 40S RIBOSOMAL SUBUNIT IN COMPLEX WITH EIF1 AND EIF1A
| |||||||||||
