1gen
From Proteopedia
(New page: 200px<br /> <applet load="1gen" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gen, resolution 2.15Å" /> '''C-TERMINAL DOMAIN O...) |
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caption="1gen, resolution 2.15Å" /> | caption="1gen, resolution 2.15Å" /> | ||
'''C-TERMINAL DOMAIN OF GELATINASE A'''<br /> | '''C-TERMINAL DOMAIN OF GELATINASE A'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of the haemopexin-like C-terminal domain of | + | The crystal structure of the haemopexin-like C-terminal domain of gelatinase A reveals that it is a four-bladed beta-propeller protein. The four blades are arranged around a channel-like opening in which Ca2+ and a Na-Cl+ ion pair are bound. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GEN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CA, CL and NA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] Full crystallographic information is available from [http:// | + | 1GEN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GEN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Collier, I | + | [[Category: Collier, I E.]] |
| - | [[Category: Gittis, A | + | [[Category: Gittis, A G.]] |
| - | [[Category: Goldberg, G | + | [[Category: Goldberg, G G.]] |
| - | [[Category: Lattman, E | + | [[Category: Lattman, E E.]] |
| - | [[Category: Libson, A | + | [[Category: Libson, A M.]] |
| - | [[Category: Marmer, B | + | [[Category: Marmer, B L.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: CL]] | [[Category: CL]] | ||
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[[Category: metalloprotease]] | [[Category: metalloprotease]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:49:13 2008'' |
Revision as of 10:49, 21 February 2008
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C-TERMINAL DOMAIN OF GELATINASE A
Contents |
Overview
The crystal structure of the haemopexin-like C-terminal domain of gelatinase A reveals that it is a four-bladed beta-propeller protein. The four blades are arranged around a channel-like opening in which Ca2+ and a Na-Cl+ ion pair are bound.
Disease
Known diseases associated with this structure: Osteolysis, idiopathic, Saudi type OMIM:[120360], Winchester syndrome OMIM:[120360]
About this Structure
1GEN is a Single protein structure of sequence from Homo sapiens with , , and as ligands. Active as Gelatinase A, with EC number 3.4.24.24 Full crystallographic information is available from OCA.
Reference
Crystal structure of the haemopexin-like C-terminal domain of gelatinase A., Libson AM, Gittis AG, Collier IE, Marmer BL, Goldberg GI, Lattman EE, Nat Struct Biol. 1995 Nov;2(11):938-42. PMID:7583664
Page seeded by OCA on Thu Feb 21 12:49:13 2008
Categories: Gelatinase A | Homo sapiens | Single protein | Collier, I E. | Gittis, A G. | Goldberg, G G. | Lattman, E E. | Libson, A M. | Marmer, B L. | CA | CL | NA | ZN | Hemopexin domain | Hydrolase | Metalloprotease
