1i7e

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[[Image:1i7e.gif|left|200px]]
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{{Seed}}
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[[Image:1i7e.png|left|200px]]
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{{STRUCTURE_1i7e| PDB=1i7e | SCENE= }}
{{STRUCTURE_1i7e| PDB=1i7e | SCENE= }}
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'''C-Terminal Domain Of Mouse Brain Tubby Protein bound to Phosphatidylinositol 4,5-bis-phosphate'''
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===C-Terminal Domain Of Mouse Brain Tubby Protein bound to Phosphatidylinositol 4,5-bis-phosphate===
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==Overview==
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Dysfunction of the tubby protein results in maturity-onset obesity in mice. Tubby has been implicated as a transcription regulator, but details of the molecular mechanism underlying its function remain unclear. Here we show that tubby functions in signal transduction from heterotrimeric GTP-binding protein (G protein)-coupled receptors. Tubby localizes to the plasma membrane by binding phosphatidylinositol 4,5-bisphosphate through its carboxyl terminal "tubby domain." X-ray crystallography reveals the atomic-level basis of this interaction and implicates tubby domains as phosphorylated-phosphatidyl- inositol binding factors. Receptor-mediated activation of G protein alphaq (Galphaq) releases tubby from the plasma membrane through the action of phospholipase C-beta, triggering translocation of tubby to the cell nucleus. The localization of tubby-like protein 3 (TULP3) is similarly regulated. These data suggest that tubby proteins function as membrane-bound transcription regulators that translocate to the nucleus in response to phosphoinositide hydrolysis, providing a direct link between G-protein signaling and the regulation of gene expression.
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The line below this paragraph, {{ABSTRACT_PUBMED_11375483}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11375483 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11375483}}
==About this Structure==
==About this Structure==
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[[Category: Shapiro, L.]]
[[Category: Shapiro, L.]]
[[Category: Tubby filled-barrel beta-barrel filled-beta-roll 12-stranded-beta-barrel helix-filled-barrel obesity blindness deafness phosphoinositide phosphatidylinositol]]
[[Category: Tubby filled-barrel beta-barrel filled-beta-roll 12-stranded-beta-barrel helix-filled-barrel obesity blindness deafness phosphoinositide phosphatidylinositol]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:39:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:31:52 2008''

Revision as of 07:31, 1 July 2008

Image:1i7e.png

Template:STRUCTURE 1i7e

C-Terminal Domain Of Mouse Brain Tubby Protein bound to Phosphatidylinositol 4,5-bis-phosphate

Template:ABSTRACT PUBMED 11375483

About this Structure

1I7E is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

G-protein signaling through tubby proteins., Santagata S, Boggon TJ, Baird CL, Gomez CA, Zhao J, Shan WS, Myszka DG, Shapiro L, Science. 2001 Jun 15;292(5524):2041-50. Epub 2001 May 24. PMID:11375483

Page seeded by OCA on Tue Jul 1 10:31:52 2008

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