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| - | [[Image:1i8l.gif|left|200px]] | + | {{Seed}} |
| | + | [[Image:1i8l.png|left|200px]] |
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| | {{STRUCTURE_1i8l| PDB=1i8l | SCENE= }} | | {{STRUCTURE_1i8l| PDB=1i8l | SCENE= }} |
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| - | '''HUMAN B7-1/CTLA-4 CO-STIMULATORY COMPLEX'''
| + | ===HUMAN B7-1/CTLA-4 CO-STIMULATORY COMPLEX=== |
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| - | ==Overview==
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| - | Optimal immune responses require both an antigen-specific and a co-stimulatory signal. The shared ligands B7-1 and B7-2 on antigen-presenting cells deliver the co-stimulatory signal through CD28 and CTLA-4 on T cells. Signalling through CD28 augments the T-cell response, whereas CTLA-4 signalling attenuates it. Numerous animal studies and recent clinical trials indicate that manipulating these interactions holds considerable promise for immunotherapy. With the consequences of these signals well established, and details of the downstream signalling events emerging, understanding the molecular nature of these extracellular interactions becomes crucial. Here we report the crystal structure of the human CTLA-4/B7-1 co-stimulatory complex at 3.0 A resolution. In contrast to other interacting cell-surface molecules, the relatively small CTLA-4/B7-1 binding interface exhibits an unusually high degree of shape complementarity. CTLA-4 forms homodimers through a newly defined interface of highly conserved residues. In the crystal lattice, CTLA-4 and B7-1 pack in a strikingly periodic arrangement in which bivalent CTLA-4 homodimers bridge bivalent B7-1 homodimers. This zipper-like oligomerization provides the structural basis for forming unusually stable signalling complexes at the T-cell surface, underscoring the importance of potent inhibitory signalling in human immune responses.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_11279502}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 11279502 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_11279502}} |
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| | ==About this Structure== | | ==About this Structure== |
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| | [[Category: Inhibitory complex]] | | [[Category: Inhibitory complex]] |
| | [[Category: Receptor]] | | [[Category: Receptor]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:42:31 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:35:16 2008'' |
Revision as of 07:35, 1 July 2008
Template:STRUCTURE 1i8l
HUMAN B7-1/CTLA-4 CO-STIMULATORY COMPLEX
Template:ABSTRACT PUBMED 11279502
About this Structure
1I8L is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses., Stamper CC, Zhang Y, Tobin JF, Erbe DV, Ikemizu S, Davis SJ, Stahl ML, Seehra J, Somers WS, Mosyak L, Nature. 2001 Mar 29;410(6828):608-11. PMID:11279502
Page seeded by OCA on Tue Jul 1 10:35:16 2008
