5r68
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5r68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5R68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5R68 FirstGlance]. <br> | <table><tr><td colspan='2'>[[5r68]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5R68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5R68 FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RYD:(1-methylbenzotriazol-5-yl)methanol'>RYD</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RYD:(1-methylbenzotriazol-5-yl)methanol'>RYD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5r68 OCA], [https://pdbe.org/5r68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5r68 RCSB], [https://www.ebi.ac.uk/pdbsum/5r68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5r68 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5r68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5r68 OCA], [https://pdbe.org/5r68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5r68 RCSB], [https://www.ebi.ac.uk/pdbsum/5r68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5r68 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/YETS4_HUMAN YETS4_HUMAN] Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.<ref>PMID:14966270</ref> | |
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
XChem group deposition -- Crystal Structure of human YEATS4 in complex with FM000199e
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Edwards A | Huber KVM | Krojer T | Raux B | Von Delft F
