1i9t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1i9t.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1i9t.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1i9t| PDB=1i9t | SCENE= }}
{{STRUCTURE_1i9t| PDB=1i9t | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE OXIDIZED RNA TRIPHOSPHATASE DOMAIN OF MOUSE MRNA CAPPING ENZYME'''
+
===CRYSTAL STRUCTURE OF THE OXIDIZED RNA TRIPHOSPHATASE DOMAIN OF MOUSE MRNA CAPPING ENZYME===
-
==Overview==
+
<!--
-
The 5' capping of mammalian pre-mRNAs is initiated by RNA triphosphatase, a member of the cysteine phosphatase superfamily. Here we report the 1.65 A crystal structure of mouse RNA triphosphatase, which reveals a deep, positively charged active site pocket that can fit a 5' triphosphate end. Structural, biochemical and mutational results show that despite sharing an HCxxxxxR(S/T) motif, a phosphoenzyme intermediate and a core alpha/beta-fold with other cysteine phosphatases, the mechanism of phosphoanhydride cleavage by mammalian capping enzyme differs from that used by protein phosphatases to hydrolyze phosphomonoesters. The most significant difference is the absence of a carboxylate general acid catalyst in RNA triphosphatase. Residues conserved uniquely among the RNA phosphatase subfamily are important for function in cap formation and are likely to play a role in substrate recognition.
+
The line below this paragraph, {{ABSTRACT_PUBMED_11350947}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 11350947 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_11350947}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Mrna capping enzyme]]
[[Category: Mrna capping enzyme]]
[[Category: Rna triphosphatase domain]]
[[Category: Rna triphosphatase domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:45:04 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:38:20 2008''

Revision as of 07:38, 1 July 2008

Image:1i9t.png

Template:STRUCTURE 1i9t

CRYSTAL STRUCTURE OF THE OXIDIZED RNA TRIPHOSPHATASE DOMAIN OF MOUSE MRNA CAPPING ENZYME

Template:ABSTRACT PUBMED 11350947

About this Structure

1I9T is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme., Changela A, Ho CK, Martins A, Shuman S, Mondragon A, EMBO J. 2001 May 15;20(10):2575-86. PMID:11350947

Page seeded by OCA on Tue Jul 1 10:38:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1i9t"
Personal tools