1iai

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[[Image:1iai.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1iai| PDB=1iai | SCENE= }}
{{STRUCTURE_1iai| PDB=1iai | SCENE= }}
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'''IDIOTYPE-ANTI-IDIOTYPE FAB COMPLEX'''
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===IDIOTYPE-ANTI-IDIOTYPE FAB COMPLEX===
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==Overview==
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Anti-idiotypic monoclonal antibody 409.5.3 is raised against an antibody that neutralizes feline infectious peritonitis virus. This antibody, used as an immunogen, elicits the production of anti-anti-idiotypic antibodies that in turn neutralize the virus. The crystal structure of the complex between anti-idiotypic Fab 409.5.3 and idiotypic Fab fragment of virus-neutralizing antibody has been solved by molecular replacement using real-space Patterson search and filtering by Patterson correlation-coefficient refinement. The structure has been refined to an R value of 0.21 based on 21,310 unique reflections between 40.0 and 2.9 A. The three-dimensional structure reveals extensive, specific interactions that involve 118 van der Waals contacts and at least 9 probable hydrogen bonds. The two Fabs are rotated 61 degrees with respect to each other around the approximate long axis of the complex and are within 26 degrees being aligned along their major axes.
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(as it appears on PubMed at http://www.pubmed.gov), where 8127852 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8127852}}
==About this Structure==
==About this Structure==
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[[Category: Hasel, K.]]
[[Category: Hasel, K.]]
[[Category: McPherson, A.]]
[[Category: McPherson, A.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:40:02 2008''

Revision as of 07:40, 1 July 2008

Image:1iai.png

Template:STRUCTURE 1iai

IDIOTYPE-ANTI-IDIOTYPE FAB COMPLEX

Template:ABSTRACT PUBMED 8127852

About this Structure

1IAI is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of an idiotype-anti-idiotype Fab complex., Ban N, Escobar C, Garcia R, Hasel K, Day J, Greenwood A, McPherson A, Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1604-8. PMID:8127852

Page seeded by OCA on Tue Jul 1 10:40:02 2008

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