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7xox
From Proteopedia
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| - | | + | #REDIRECT [[8ia7]] This PDB entry is obsolete and replaced by 8ia7 |
| - | ==Structural insights into human brain gut peptide cholecystokinin receptors==
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| - | <StructureSection load='7xox' size='340' side='right'caption='[[7xox]], [[Resolution|resolution]] 3.10Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[7xox]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XOX FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xox OCA], [https://pdbe.org/7xox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xox RCSB], [https://www.ebi.ac.uk/pdbsum/7xox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xox ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[https://www.uniprot.org/uniprot/GASR_HUMAN GASR_HUMAN]] Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<ref>PMID:8349705</ref> <ref>PMID:8185170</ref> <ref>PMID:7848914</ref> <ref>PMID:10913157</ref> <ref>PMID:11495676</ref> <ref>PMID:8221657</ref> Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.<ref>PMID:8349705</ref> <ref>PMID:8185170</ref> <ref>PMID:7848914</ref> <ref>PMID:10913157</ref> <ref>PMID:11495676</ref> <ref>PMID:8221657</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Large Structures]]
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| - | [[Category: Mus musculus]]
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| - | [[Category: Chen L]]
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| - | [[Category: Ding Y]]
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| - | [[Category: Ji S]]
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| - | [[Category: Liao Y]]
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| - | [[Category: Zhang H]]
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Current revision
- REDIRECT 8ia7 This PDB entry is obsolete and replaced by 8ia7
