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== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/SRC8_MOUSE SRC8_MOUSE] Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.<ref>PMID:17403031</ref> <ref>PMID:22262902</ref> | |
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Structure of the murine cortactin C-SH3 domain in complex with a Pyk2 proline-rich ligand
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