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1ibn

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[[Image:1ibn.gif|left|200px]]
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[[Image:1ibn.png|left|200px]]
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==Overview==
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{{ABSTRACT_11473264}}
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The N-terminal domain of the influenza hemagglutinin (HA) is the only portion of the molecule that inserts deeply into membranes of infected cells to mediate the viral and the host cell membrane fusion. This domain constitutes an autonomous folding unit in the membrane, causes hemolysis of red blood cells and catalyzes lipid exchange between juxtaposed membranes in a pH-dependent manner. Combining NMR structures determined at pHs 7.4 and 5 with EPR distance constraints, we have deduced the structures of the N-terminal domain of HA in the lipid bilayer. At both pHs, the domain is a kinked, predominantly helical amphipathic structure. At the fusogenic pH 5, however, the domain has a sharper bend, an additional 3(10)-helix and a twist, resulting in the repositioning of Glu 15 and Asp 19 relative to that at the nonfusogenic pH 7.4. Rotation of these charged residues out of the membrane plane creates a hydrophobic pocket that allows a deeper insertion of the fusion domain into the core of the lipid bilayer. Such an insertion mode could perturb lipid packing and facilitate lipid mixing between juxtaposed membranes.
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==About this Structure==
==About this Structure==
1IBN is a [[Single protein]] structure. The following page contains interesting information on the relation of 1IBN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb76_1.html Hemagglutinin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IBN OCA].
1IBN is a [[Single protein]] structure. The following page contains interesting information on the relation of 1IBN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb76_1.html Hemagglutinin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IBN OCA].
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==Reference==
 
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Membrane structure and fusion-triggering conformational change of the fusion domain from influenza hemagglutinin., Han X, Bushweller JH, Cafiso DS, Tamm LK, Nat Struct Biol. 2001 Aug;8(8):715-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11473264 11473264]
 
[[Category: Hemagglutinin]]
[[Category: Hemagglutinin]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Tamm, L K.]]
[[Category: Tamm, L K.]]
[[Category: Helix-kink-helix]]
[[Category: Helix-kink-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:48:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 17:32:12 2008''

Revision as of 14:32, 26 June 2008

Image:1ibn.png

Template:STRUCTURE 1ibn

NMR STRUCTURE OF HEMAGGLUTININ FUSION PEPTIDE IN DPC MICELLES AT PH 5


Template:ABSTRACT 11473264

About this Structure

1IBN is a Single protein structure. The following page contains interesting information on the relation of 1IBN with [Hemagglutinin]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 17:32:12 2008

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