1ich

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[[Image:1ich.gif|left|200px]]
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{{Seed}}
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[[Image:1ich.png|left|200px]]
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{{STRUCTURE_1ich| PDB=1ich | SCENE= }}
{{STRUCTURE_1ich| PDB=1ich | SCENE= }}
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'''SOLUTION STRUCTURE OF THE TUMOR NECROSIS FACTOR RECEPTOR-1 DEATH DOMAIN'''
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===SOLUTION STRUCTURE OF THE TUMOR NECROSIS FACTOR RECEPTOR-1 DEATH DOMAIN===
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==Overview==
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Tumor necrosis factor receptor-1 death domain (TNFR-1 DD) is the intracellular functional domain responsible for the receptor signaling activities. The solution structure of the R347K mutant of TNFR-1 DD was solved by NMR spectroscopy. A total of 20 structures were calculated by means of hybrid distance geometry-simulated annealing using a total of 1167 distance constraints and 117 torsion angle constraints. The atomic rms distribution about the mean coordinate positions for the 20 structures for residues composing the secondary structure region is 0.40 A for the backbone atoms and 1.09 A for all atoms. The structure consists of six antiparallel alpha-helices arranged in a similar fashion to the other members of the death domain superfamily. The secondary structure and three-dimensional structure of R347K TNFR1-DD are very similar to the secondary structure and deduced topology of the R347A TNFR1-DD mutant. Mutagenesis studies identified critical residues located in alpha2 and part of alpha3 and alpha4 that are crucial for self-interaction and interaction with TRADD. Structural superposition with previously solved proteins in the death domain superfamily reveals that the major differences between the structures reside in alpha2, alpha3, and alpha4. Interestingly, these regions correspond to the binding sites of TNFR1-DD, providing a structural basis for the specificity of death domain interactions and its subsequent signaling event.
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The line below this paragraph, {{ABSTRACT_PUBMED_11453696}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11453696 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11453696}}
==About this Structure==
==About this Structure==
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1ICH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICH OCA].
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1ICH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICH OCA].
==Reference==
==Reference==
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[[Category: Xu, G Y.]]
[[Category: Xu, G Y.]]
[[Category: Death domain]]
[[Category: Death domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:50:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:45:33 2008''

Revision as of 07:45, 1 July 2008

Image:1ich.png

Template:STRUCTURE 1ich

SOLUTION STRUCTURE OF THE TUMOR NECROSIS FACTOR RECEPTOR-1 DEATH DOMAIN

Template:ABSTRACT PUBMED 11453696

About this Structure

1ICH is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the tumor necrosis factor receptor-1 death domain., Sukits SF, Lin LL, Hsu S, Malakian K, Powers R, Xu GY, J Mol Biol. 2001 Jul 20;310(4):895-906. PMID:11453696

Page seeded by OCA on Tue Jul 1 10:45:33 2008

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