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1icx

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[[Image:1icx.jpg|left|200px]]
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{{STRUCTURE_1icx| PDB=1icx | SCENE= }}
{{STRUCTURE_1icx| PDB=1icx | SCENE= }}
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'''CRYSTAL STRUCTURE OF PATHOGENESIS-RELATED PROTEIN LLPR10.1A FROM YELLOW LUPINE'''
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===CRYSTAL STRUCTURE OF PATHOGENESIS-RELATED PROTEIN LLPR10.1A FROM YELLOW LUPINE===
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==Overview==
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Pathogenesis-related class 10 (PR10) proteins are restricted to the plant kingdom where they are coded by multigene families and occur at high levels. In spite of their abundance, their physiological role is obscure although members of a distantly related subclass (cytokinin-specific binding proteins) are known to bind plant hormones. PR10 proteins are of special significance in legume plants where their expression patterns are related to infection by the symbiotic, nitrogen-fixing bacteria. Here we present the first crystal structures of classic PR10 proteins representing two homologues from one subclass in yellow lupine. The general fold is similar and, as in a birch pollen allergen, consists of a seven-stranded beta-sheet wrapped around a long C-terminal helix. The mouth of a large pocket formed between the beta-sheet and the helix seems a likely site for ligand binding. The shape of the pocket varies because, in variance with the rigid beta-sheet, the helix shows unusual conformational variability consisting in bending, disorder, and axial shifting. A surface loop, proximal to the entrance to the internal cavity, shows an unusual structural conservation and rigidity in contrast to the high glycine content in its sequence. The loop is different from the so-called glycine-rich P-loops that bind phosphate groups of nucleotides, but it is very likely that it does play a role in ligand binding in PR10 proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 12079359 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12079359}}
==About this Structure==
==About this Structure==
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[[Category: 7-stranded beta sheet]]
[[Category: 7-stranded beta sheet]]
[[Category: C-terminal helix]]
[[Category: C-terminal helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:51:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:46:43 2008''

Revision as of 07:46, 1 July 2008

Image:1icx.png

Template:STRUCTURE 1icx

CRYSTAL STRUCTURE OF PATHOGENESIS-RELATED PROTEIN LLPR10.1A FROM YELLOW LUPINE

Template:ABSTRACT PUBMED 12079359

About this Structure

1ICX is a Single protein structure of sequence from Lupinus luteus. Full crystallographic information is available from OCA.

Reference

Crystal structures of two homologous pathogenesis-related proteins from yellow lupine., Biesiadka J, Bujacz G, Sikorski MM, Jaskolski M, J Mol Biol. 2002 Jun 21;319(5):1223-34. PMID:12079359

Page seeded by OCA on Tue Jul 1 10:46:43 2008

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