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== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/TEAD3_MOUSE TEAD3_MOUSE] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity). | |
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 19:35, 19 October 2022
Crystal structure of TEAD3 in complex with CPD4
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