1ido

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{{STRUCTURE_1ido| PDB=1ido | SCENE= }}
{{STRUCTURE_1ido| PDB=1ido | SCENE= }}
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'''I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND'''
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===I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND===
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==Overview==
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We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule. We suggest that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands. We further propose that the beta subunits of integrins contain a MIDAS motif within a modified A domain. Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs.
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(as it appears on PubMed at http://www.pubmed.gov), where 7867070 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7867070}}
==About this Structure==
==About this Structure==
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Integrin]]
[[Category: Integrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:53:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:48:43 2008''

Revision as of 07:48, 1 July 2008

Image:1ido.png

Template:STRUCTURE 1ido

I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND

Template:ABSTRACT PUBMED 7867070

About this Structure

1IDO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:7867070

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