1idy

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[[Image:1idy.gif|left|200px]]
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{{Seed}}
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[[Image:1idy.png|left|200px]]
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{{STRUCTURE_1idy| PDB=1idy | SCENE= }}
{{STRUCTURE_1idy| PDB=1idy | SCENE= }}
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'''STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE'''
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===STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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A small globular protein, the third repeat of the c-Myb DNA-binding domain, which is composed of 54 amino acid residues, was engineered so as to understand the structural uniqueness of native proteins. This small protein has three alpha-helices that form a helix-turn-helix structure, which is maintained by the hydrophobic core with three Ile residues. One of the mutant proteins, with two of the buried Ile (Ile-155 and Ile-181) substituted with Leu residues, showed multiple conformations, as monitored by heteronuclear magnetic resonance spectroscopy for 13C- and 15N-labeled proteins. The increase in the side-chain conformational entropy, caused by changing the Ile to a Leu residue on an alpha-helix, could engender the lack of structural uniqueness. In native proteins, the conformations of not only the beta-branched side chains, but also those of the neighboring bulky side chains, can be greatly restricted, depending upon the local backbone structure.
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The line below this paragraph, {{ABSTRACT_PUBMED_8942977}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8942977 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8942977}}
==About this Structure==
==About this Structure==
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1IDY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IDY OCA].
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1IDY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IDY OCA].
==Reference==
==Reference==
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[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
[[Category: Protooncogene product]]
[[Category: Protooncogene product]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:53:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:49:27 2008''

Revision as of 07:49, 1 July 2008

Image:1idy.png

Template:STRUCTURE 1idy

STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 8942977

About this Structure

1IDY is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

A small engineered protein lacks structural uniqueness by increasing the side-chain conformational entropy., Furukawa K, Oda M, Nakamura H, Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13583-8. PMID:8942977

Page seeded by OCA on Tue Jul 1 10:49:27 2008

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