1ie0

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[[Image:1ie0.gif|left|200px]]
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{{STRUCTURE_1ie0| PDB=1ie0 | SCENE= }}
{{STRUCTURE_1ie0| PDB=1ie0 | SCENE= }}
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'''CRYSTAL STRUCTURE OF LUXS'''
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===CRYSTAL STRUCTURE OF LUXS===
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==Overview==
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The ability of bacteria to regulate gene expression in response to changes in cell density is termed quorum sensing. This behavior involves the synthesis and recognition of extracellular, hormone-like compounds known as autoinducers. Here we report the structure of an autoinducer synthase, LuxS from Bacillus subtilis, at 1.6-A resolution (R(free) = 0.204; R(work) = 0.174). LuxS is a homodimeric enzyme with a novel fold that incorporates two identical tetrahedral metal-binding sites. This metal center is composed of a Zn(2+) atom coordinated by two histidines, a cysteine, and a solvent molecule, and is reminiscent of active sites found in several peptidases and amidases. Although the nature of the autoinducer synthesized by LuxS cannot be deduced from the crystal structure, features of the putative active site suggest that LuxS might catalyze hydrolytic, but not proteolytic, cleavage of a small substrate. Our analysis represents a test of structure-based functional assignment.
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(as it appears on PubMed at http://www.pubmed.gov), where 11553770 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11553770}}
==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:53:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:49:28 2008''

Revision as of 07:49, 1 July 2008

Image:1ie0.png

Template:STRUCTURE 1ie0

CRYSTAL STRUCTURE OF LUXS

Template:ABSTRACT PUBMED 11553770

About this Structure

1IE0 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Crystal structure of the quorum-sensing protein LuxS reveals a catalytic metal site., Hilgers MT, Ludwig ML, Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11169-74. Epub 2001 Sep 11. PMID:11553770

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