1gnh
From Proteopedia
(New page: 200px<br /> <applet load="1gnh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gnh, resolution 3.0Å" /> '''HUMAN C-REACTIVE PRO...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1gnh.gif|left|200px]]<br /> | + | [[Image:1gnh.gif|left|200px]]<br /><applet load="1gnh" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1gnh" size=" | + | |
caption="1gnh, resolution 3.0Å" /> | caption="1gnh, resolution 3.0Å" /> | ||
'''HUMAN C-REACTIVE PROTEIN'''<br /> | '''HUMAN C-REACTIVE PROTEIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of the classical acute phase reactant human C-reactive | + | The structure of the classical acute phase reactant human C-reactive protein provides evidence that phosphocholine binding is mediated through calcium and a hydrophobic pocket centred on Phe 66. The residue Glu 81 is suitably positioned to interact with the choline group. A cleft on the pentameric face opposite to that containing the calcium site may have an important functional role. The structure provides insights into the molecular mechanisms by which this highly conserved plasma protein, for which no polymorphism or deficiency state is known, may exert its biological role. |
==Disease== | ==Disease== | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1GNH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1GNH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNH OCA]. |
==Reference== | ==Reference== | ||
| Line 17: | Line 16: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Bloomer, A | + | [[Category: Bloomer, A C.]] |
| - | [[Category: Cheetham, G | + | [[Category: Cheetham, G M.T.]] |
| - | [[Category: Greenhough, T | + | [[Category: Greenhough, T J.]] |
[[Category: Holden, D.]] | [[Category: Holden, D.]] | ||
| - | [[Category: Myles, D | + | [[Category: Myles, D A.]] |
| - | [[Category: Pepys, M | + | [[Category: Pepys, M B.]] |
| - | [[Category: Shrive, A | + | [[Category: Shrive, A K.]] |
| - | [[Category: Turnell, W | + | [[Category: Turnell, W G.]] |
| - | [[Category: Volanakis, J | + | [[Category: Volanakis, J E.]] |
[[Category: CA]] | [[Category: CA]] | ||
[[Category: acute-phase protein]] | [[Category: acute-phase protein]] | ||
| Line 31: | Line 30: | ||
[[Category: pentraxin]] | [[Category: pentraxin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:51:56 2008'' |
Revision as of 10:52, 21 February 2008
|
HUMAN C-REACTIVE PROTEIN
Contents |
Overview
The structure of the classical acute phase reactant human C-reactive protein provides evidence that phosphocholine binding is mediated through calcium and a hydrophobic pocket centred on Phe 66. The residue Glu 81 is suitably positioned to interact with the choline group. A cleft on the pentameric face opposite to that containing the calcium site may have an important functional role. The structure provides insights into the molecular mechanisms by which this highly conserved plasma protein, for which no polymorphism or deficiency state is known, may exert its biological role.
Disease
Known disease associated with this structure: Specific granule deficiency OMIM:[600749]
About this Structure
1GNH is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Three dimensional structure of human C-reactive protein., Shrive AK, Cheetham GM, Holden D, Myles DA, Turnell WG, Volanakis JE, Pepys MB, Bloomer AC, Greenhough TJ, Nat Struct Biol. 1996 Apr;3(4):346-54. PMID:8599761
Page seeded by OCA on Thu Feb 21 12:51:56 2008
