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1ien

From Proteopedia

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[[Image:1ien.gif|left|200px]]
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[[Image:1ien.png|left|200px]]
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{{STRUCTURE_1ien| PDB=1ien | SCENE= }}
{{STRUCTURE_1ien| PDB=1ien | SCENE= }}
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'''SOLUTION STRUCTURE OF TIA'''
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===SOLUTION STRUCTURE OF TIA===
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==Overview==
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Cone snails use venom containing a cocktail of peptides ('conopeptides') to capture their prey. Many of these peptides also target mammalian receptors, often with exquisite selectivity. Here we report the discovery of two new classes of conopeptides. One class targets alpha1-adrenoceptors (rho-TIA from the fish-hunting Conus tulipa), and the second class targets the neuronal noradrenaline transporter (chi-MrIA and chi-MrIB from the mollusk-hunting C. marmoreus). rho-TIA and chi-MrIA selectively modulate these important membrane-bound proteins. Both peptides act as reversible non-competitive inhibitors and provide alternative avenues for the identification of inhibitor drugs.
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The line below this paragraph, {{ABSTRACT_PUBMED_11528421}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11528421 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11528421}}
==About this Structure==
==About this Structure==
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1IEN is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEN OCA].
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1IEN is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IEN OCA].
==Reference==
==Reference==
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[[Category: Alpha1-adrenoceptor]]
[[Category: Alpha1-adrenoceptor]]
[[Category: Conotoxin]]
[[Category: Conotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:55:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:51:18 2008''

Revision as of 07:51, 1 July 2008

Image:1ien.png

Template:STRUCTURE 1ien

SOLUTION STRUCTURE OF TIA

Template:ABSTRACT PUBMED 11528421

About this Structure

1IEN is a Single protein structure. Full experimental information is available from OCA.

Reference

Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter., Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ, Nat Neurosci. 2001 Sep;4(9):902-7. PMID:11528421

Page seeded by OCA on Tue Jul 1 10:51:18 2008

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