1go5
From Proteopedia
(New page: 200px<br /> <applet load="1go5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1go5" /> '''STRUCTURE OF THE C-TERMINAL FG-BINDING DOMA...) |
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'''STRUCTURE OF THE C-TERMINAL FG-BINDING DOMAIN OF HUMAN TAP'''<br /> | '''STRUCTURE OF THE C-TERMINAL FG-BINDING DOMAIN OF HUMAN TAP'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1GO5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1GO5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GO5 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: uba]] | [[Category: uba]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:54:31 2008'' |
Revision as of 13:54, 15 February 2008
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STRUCTURE OF THE C-TERMINAL FG-BINDING DOMAIN OF HUMAN TAP
Contents |
Overview
The vertebrate Tap protein is a member of the NXF family of shuttling, transport receptors for nuclear export of mRNA. Tap has a modular, structure, and its most C-terminal domain is important for binding to FG, repeat-containing nuclear pore proteins (FG-nucleoporins) and is, sufficient to mediate nuclear shuttling. We report the solution structure, of this C-terminal domain, which is based on a distinctive arrangement of, four alpha-helices and is joined to the next module by a flexible, 12-residue Pro-rich linker. F617A Tap suppresses FG-nucleoporin binding by, the most C-terminal domain that, together with the structure of the other, modules from which Tap is constructed, provides a structural context for, its nuclear shuttling function.
Disease
Known diseases associated with this structure: Bare lymphocyte syndrome, type I OMIM:[170260]
About this Structure
1GO5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1., Grant RP, Hurt E, Neuhaus D, Stewart M, Nat Struct Biol. 2002 Apr;9(4):247-51. PMID:11875519
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