8e28
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human Dis3L2 in complex with hairpin A-GCU14== | |
| - | + | <StructureSection load='8e28' size='340' side='right'caption='[[8e28]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8e28]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E28 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e28 OCA], [https://pdbe.org/8e28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e28 RCSB], [https://www.ebi.ac.uk/pdbsum/8e28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e28 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/DI3L2_HUMAN DI3L2_HUMAN] Perlman syndrome;Nephroblastoma. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DI3L2_HUMAN DI3L2_HUMAN] 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.[HAMAP-Rule:MF_03045]<ref>PMID:23756462</ref> <ref>PMID:24141620</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Joshua-Tor L]] | ||
| + | [[Category: Meze K]] | ||
| + | [[Category: Thomas DR]] | ||
Revision as of 06:04, 2 March 2023
Human Dis3L2 in complex with hairpin A-GCU14
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