7usc
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN] Angelman syndrome. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CYFP1_HUMAN CYFP1_HUMAN] Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.<ref>PMID:9417078</ref> <ref>PMID:16260607</ref> <ref>PMID:19524508</ref> <ref>PMID:21107423</ref> | |
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 07:46, 9 November 2022
Cryo-EM structure of WAVE Regulatory Complex
| |||||||||||
Categories: Homo sapiens | Large Structures | Chen B | Chowdhury S | Ding B | Yang S
