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1ig4

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[[Image:1ig4.gif|left|200px]]
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{{STRUCTURE_1ig4| PDB=1ig4 | SCENE= }}
{{STRUCTURE_1ig4| PDB=1ig4 | SCENE= }}
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'''Solution Structure of the Methyl-CpG-Binding Domain of Human MBD1 in Complex with Methylated DNA'''
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===Solution Structure of the Methyl-CpG-Binding Domain of Human MBD1 in Complex with Methylated DNA===
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==Overview==
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In vertebrates, the biological consequences of DNA methylation are often mediated by protein factors containing conserved methyl-CpG binding domains (MBDs). Mutations in the MBD protein MeCP2 cause the neurodevelopmental disease Rett syndrome. We report here the solution structure of the MBD of the human methylation-dependent transcriptional regulator MBD1 bound to methylated DNA. DNA binding causes a loop in MBD1 to fold into a major and novel DNA binding interface. Recognition of the methyl groups and CG sequence at the methylation site is due to five highly conserved residues that form a hydrophobic patch. The structure indicates how MBD may access nucleosomal DNA without encountering steric interference from core histones, and provides a basis to interpret mutations linked to Rett syndrome in MeCP2.
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{{ABSTRACT_PUBMED_11371345}}
==About this Structure==
==About this Structure==
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1IG4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG4 OCA].
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1IG4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG4 OCA].
==Reference==
==Reference==
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[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
[[Category: Recognition via beta-sheet]]
[[Category: Recognition via beta-sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:57:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:56:40 2008''

Revision as of 07:56, 1 July 2008

Image:1ig4.png

Template:STRUCTURE 1ig4

Solution Structure of the Methyl-CpG-Binding Domain of Human MBD1 in Complex with Methylated DNA

Template:ABSTRACT PUBMED 11371345

About this Structure

1IG4 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA., Ohki I, Shimotake N, Fujita N, Jee J, Ikegami T, Nakao M, Shirakawa M, Cell. 2001 May 18;105(4):487-97. PMID:11371345

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