1ig9

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{{STRUCTURE_1ig9| PDB=1ig9 | SCENE= }}
{{STRUCTURE_1ig9| PDB=1ig9 | SCENE= }}
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'''Structure of the Replicating Complex of a Pol Alpha Family DNA Polymerase'''
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===Structure of the Replicating Complex of a Pol Alpha Family DNA Polymerase===
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==Overview==
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We describe the 2.6 A resolution crystal structure of RB69 DNA polymerase with primer-template DNA and dTTP, capturing the step just before primer extension. This ternary complex structure in the human DNA polymerase alpha family shows a 60 degrees rotation of the fingers domain relative to the apo-protein structure, similar to the fingers movement in pol I family polymerases. Minor groove interactions near the primer 3' terminus suggest a common fidelity mechanism for pol I and pol alpha family polymerases. The duplex product DNA orientation differs by 40 degrees between the polymerizing mode and editing mode structures. The role of the thumb in this DNA motion provides a model for editing in the pol alpha family.
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(as it appears on PubMed at http://www.pubmed.gov), where 11389835 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11389835}}
==About this Structure==
==About this Structure==
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[[Category: Fidelity]]
[[Category: Fidelity]]
[[Category: Two metal ion mechanism]]
[[Category: Two metal ion mechanism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:58:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:58:01 2008''

Revision as of 07:58, 1 July 2008

Image:1ig9.png

Template:STRUCTURE 1ig9

Structure of the Replicating Complex of a Pol Alpha Family DNA Polymerase

Template:ABSTRACT PUBMED 11389835

About this Structure

1IG9 is a Single protein structure of sequence from Enterobacteria phage rb69. Full crystallographic information is available from OCA.

Reference

Structure of the replicating complex of a pol alpha family DNA polymerase., Franklin MC, Wang J, Steitz TA, Cell. 2001 Jun 1;105(5):657-67. PMID:11389835

Page seeded by OCA on Tue Jul 1 10:58:01 2008

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