1ih1

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{{STRUCTURE_1ih1| PDB=1ih1 | SCENE= }}
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'''Crystal Structure of the B-DNA Hexamer GGCGCC with Cobalt Hexamine Resolved to 2.0 Angstroms'''
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===Crystal Structure of the B-DNA Hexamer GGCGCC with Cobalt Hexamine Resolved to 2.0 Angstroms===
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==Overview==
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The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.
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(as it appears on PubMed at http://www.pubmed.gov), where 11390969 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11390969}}
==About this Structure==
==About this Structure==
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[[Category: Dna transition]]
[[Category: Dna transition]]
[[Category: Structural transition]]
[[Category: Structural transition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:59:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:09:53 2008''

Revision as of 09:09, 1 July 2008

Image:1ih1.png

Template:STRUCTURE 1ih1

Crystal Structure of the B-DNA Hexamer GGCGCC with Cobalt Hexamine Resolved to 2.0 Angstroms

Template:ABSTRACT PUBMED 11390969

About this Structure

Full crystallographic information is available from OCA.

Reference

A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:11390969

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