1ih5

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[[Image:1ih5.gif|left|200px]]
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{{Seed}}
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[[Image:1ih5.png|left|200px]]
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{{STRUCTURE_1ih5| PDB=1ih5 | SCENE= }}
{{STRUCTURE_1ih5| PDB=1ih5 | SCENE= }}
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'''CRYSTAL STRUCTURE OF AQUAPORIN-1'''
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===CRYSTAL STRUCTURE OF AQUAPORIN-1===
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==Overview==
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The water-selective pathway through the aquaporin-1 membrane channel has been visualized by fitting an atomic model to a 3.7-A resolution three-dimensional density map. This map was determined by analyzing images and electron diffraction patterns of lipid-reconstituted two-dimensional crystals of aquaporin-1 preserved in vitrified buffer in the absence of any additive. The aqueous pathway is characterized by a size-selective pore that is approximately 4.0 +/- 0.5A in diameter, spans a length of approximately 18A, and bends by approximately 25 degrees as it traverses the bilayer. This narrow pore is connected by wide, funnel-shaped openings at the extracellular and cytoplasmic faces. The size-selective pore is outlined mostly by hydrophobic residues, resulting in a relatively inert pathway conducive to diffusion-limited water flow. The apex of the curved pore is close to the locations of the in-plane pseudo-2-fold symmetry axis that relates the N- and C-terminal halves and the conserved, functionally important N76 and N192 residues.
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The line below this paragraph, {{ABSTRACT_PUBMED_11171962}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11171962 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11171962}}
==About this Structure==
==About this Structure==
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[[Category: Two-dimensional crystal]]
[[Category: Two-dimensional crystal]]
[[Category: Water channel]]
[[Category: Water channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:10:15 2008''

Revision as of 09:10, 1 July 2008

Image:1ih5.png

Template:STRUCTURE 1ih5

CRYSTAL STRUCTURE OF AQUAPORIN-1

Template:ABSTRACT PUBMED 11171962

About this Structure

1IH5 is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1hw0. Full crystallographic information is available from OCA.

Reference

Visualization of a water-selective pore by electron crystallography in vitreous ice., Ren G, Reddy VS, Cheng A, Melnyk P, Mitra AK, Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1398-403. Epub 2001 Jan 30. PMID:11171962

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