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1ihk

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{{STRUCTURE_1ihk| PDB=1ihk | SCENE= }}
{{STRUCTURE_1ihk| PDB=1ihk | SCENE= }}
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'''CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9)'''
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===CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9)===
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==Overview==
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Fibroblast growth factors (FGFs) constitute a large family of heparin-binding growth factors with diverse biological activities. FGF9 was originally described as glia-activating factor and is expressed in the nervous system as a potent mitogen for glia cells. Unlike most FGFs, FGF9 forms dimers in solution with a K(d) of 680 nm. To elucidate the molecular mechanism of FGF9 dimerization, the crystal structure of FGF9 was determined at 2.2 A resolution. FGF9 adopts a beta-trefoil fold similar to other FGFs. However, unlike other FGFs, the N- and C-terminal regions outside the beta-trefoil core in FGF9 are ordered and involved in the formation of a 2-fold crystallographic dimer. A significant surface area (&gt;2000 A(2)) is buried in the dimer interface that occludes a major receptor binding site of FGF9. Thus, we propose an autoinhibitory mechanism for FGF9 that is dependent on sequences outside of the beta-trefoil core. Moreover, a model is presented providing a molecular basis for the preferential affinity of FGF9 toward FGFR3.
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(as it appears on PubMed at http://www.pubmed.gov), where 11060292 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11060292}}
==About this Structure==
==About this Structure==
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[[Category: Plotnikov, A N.]]
[[Category: Plotnikov, A N.]]
[[Category: B-trefoil fold]]
[[Category: B-trefoil fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:00:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:12:27 2008''

Revision as of 09:12, 1 July 2008

Image:1ihk.png

Template:STRUCTURE 1ihk

CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 (FGF9)

Template:ABSTRACT PUBMED 11060292

About this Structure

1IHK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition., Plotnikov AN, Eliseenkova AV, Ibrahimi OA, Shriver Z, Sasisekharan R, Lemmon MA, Mohammadi M, J Biol Chem. 2001 Feb 9;276(6):4322-9. Epub 2000 Nov 1. PMID:11060292

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