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1ihv

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[[Image:1ihv.gif|left|200px]]
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{{STRUCTURE_1ihv| PDB=1ihv | SCENE= }}
{{STRUCTURE_1ihv| PDB=1ihv | SCENE= }}
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'''SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, MINIMIZED AVERAGE STRUCTURE'''
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===SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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The solution structure of the DNA binding domain of HIV-1 integrase (residues 220-270) has been determined by multidimensional NMR spectroscopy. The protein is a dimer in solution, and each subunit is composed of a five-stranded beta-barrel with a topology very similar to that of the SH3 domain. The dimer is formed by a stacked beta-interface comprising strands 2, 3, and 4, with the two triple-stranded antiparallel beta-sheets, one from each subunit, oriented antiparallel to each other. One surface of the dimer, bounded by the loop between strands beta 1 and beta 2, forms a saddle-shaped groove with dimensions of approximately 24 x 23 x 12 A in cross section. Lys264, which has been shown from mutational data to be involved in DNA binding, protrudes from this surface, implicating the saddle-shaped groove as the potential DNA binding site.
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The line below this paragraph, {{ABSTRACT_PUBMED_7632683}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7632683 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7632683}}
==About this Structure==
==About this Structure==
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1IHV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHV OCA].
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1IHV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHV OCA].
==Reference==
==Reference==
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[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
[[Category: Polyprotein]]
[[Category: Polyprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:01:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:13:40 2008''

Revision as of 09:13, 1 July 2008

Image:1ihv.png

Template:STRUCTURE 1ihv

SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 7632683

About this Structure

1IHV is a Single protein structure of sequence from Human immunodeficiency virus. Full experimental information is available from OCA.

Reference

Solution structure of the DNA binding domain of HIV-1 integrase., Lodi PJ, Ernst JA, Kuszewski J, Hickman AB, Engelman A, Craigie R, Clore GM, Gronenborn AM, Biochemistry. 1995 Aug 8;34(31):9826-33. PMID:7632683

Page seeded by OCA on Tue Jul 1 12:13:40 2008

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