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1ii6

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[[Image:1ii6.gif|left|200px]]
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{{STRUCTURE_1ii6| PDB=1ii6 | SCENE= }}
{{STRUCTURE_1ii6| PDB=1ii6 | SCENE= }}
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'''Crystal Structure of the Mitotic Kinesin Eg5 in Complex with Mg-ADP.'''
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===Crystal Structure of the Mitotic Kinesin Eg5 in Complex with Mg-ADP.===
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==Overview==
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Success of mitosis depends upon the coordinated and regulated activity of many cellular factors, including kinesin motor proteins, which are required for the assembly and function of the mitotic spindle. Eg5 is a kinesin implicated in the formation of the bipolar spindle and its movement prior to and during anaphase. We have determined the crystal structure of the Eg5 motor domain with ADP-Mg bound. This structure revealed a new intramolecular binding site of the neck-linker. In other kinesins, the neck-linker has been shown to be a critical mechanical element for force generation. The neck-linker of conventional kinesin is believed to undergo an ordered-to-disordered transition as it translocates along a microtubule. The structure of Eg5 showed an ordered neck-linker conformation in a position never observed previously. The docking of the neck-linker relies upon residues conserved only in the Eg5 subfamily of kinesin motors. Based on this new information, we suggest that the neck-linker of Eg5 may undergo an ordered-to-ordered transition during force production. This ratchet-like mechanism is consistent with the biological activity of Eg5.
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The line below this paragraph, {{ABSTRACT_PUBMED_11328809}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11328809 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11328809}}
==About this Structure==
==About this Structure==
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[[Category: Turner, J.]]
[[Category: Turner, J.]]
[[Category: Mg-adp complex]]
[[Category: Mg-adp complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:01:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:15:02 2008''

Revision as of 09:15, 1 July 2008

Image:1ii6.png

Template:STRUCTURE 1ii6

Crystal Structure of the Mitotic Kinesin Eg5 in Complex with Mg-ADP.

Template:ABSTRACT PUBMED 11328809

About this Structure

1II6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker., Turner J, Anderson R, Guo J, Beraud C, Fletterick R, Sakowicz R, J Biol Chem. 2001 Jul 6;276(27):25496-502. Epub 2001 Apr 27. PMID:11328809

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