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8b2n
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Potempin A (PotA) from Tannerella forsythia in complex with the catalytic domain of human MMP-12== | |
| - | + | <StructureSection load='8b2n' size='340' side='right'caption='[[8b2n]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8b2n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Tannerella_forsythia Tannerella forsythia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B2N FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b2n OCA], [https://pdbe.org/8b2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b2n RCSB], [https://www.ebi.ac.uk/pdbsum/8b2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b2n ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Guevara | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Tannerella forsythia]] |
| - | [[Category: | + | [[Category: Arolas JL]] |
| + | [[Category: Cuppari A]] | ||
| + | [[Category: Garcia-Ferrer I]] | ||
| + | [[Category: Goulas T]] | ||
| + | [[Category: Guevara T]] | ||
| + | [[Category: Ksiazek M]] | ||
| + | [[Category: Lopez-Pelegrin M]] | ||
| + | [[Category: Potempa J]] | ||
| + | [[Category: Rodriguez-Banqueri A]] | ||
Revision as of 09:27, 21 December 2022
Potempin A (PotA) from Tannerella forsythia in complex with the catalytic domain of human MMP-12
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